ArticlePLoS biology2009
Self-organization of dynein motors generates meiotic nuclear oscillations.
Article in PLoS biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed.
- A divergent Plasmodium NEK4 acts as a key regulator driving the early events of meiosis.Nature communications · 2026Article
- Mechanical Coupling With the Nuclear Envelope Shapes the Schizosaccharomyces pombe Mitotic Spindle.Cytoskeleton (Hoboken, N.J.) · 2026Article
- A divergentResearch square · 2025Article
- A force balance model for a cell size-dependent meiotic nuclear oscillation in fission yeast.EMBO reports · 2023Article
- Envisioning a role for nuclear actin in prophase I spermatocytes.Frontiers in cell and developmental biology · 2023Review
- Stochastic model of T cell repolarization during target elimination (II).Biophysical journal · 2022Article
- Catalase T-Deficient Fission Yeast Meiocytes Show Resistance to Ionizing Radiation.Antioxidants (Basel, Switzerland) · 2020Article
- Article
- Cortical tethering of mitochondria by the anchor protein Mcp5 enables uniparental inheritance.The Journal of cell biology · 2019Article
- Nuclear Mechanics in the Fission Yeast.Cells · 2019Review
- Pivoting of microtubules driven by minus-end-directed motors leads to spindle assembly.BMC biology · 2019Article
- Mechanical principles of nuclear shaping and positioning.The Journal of cell biology · 2018Review
- Nuclear movement in fungi.Seminars in cell & developmental biology · 2018Review
- Tumor suppressor APC is an attenuator of spindle-pulling forces duringProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Live cell X-ray imaging of autophagic vacuoles formation and chromatin dynamics in fission yeast.Scientific reports · 2017Article
- Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport.PLoS genetics · 2017Article
- Fission yeast myosin I facilitates PI(4,5)PProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast.Science advances · 2017Article
- Dynein Separately Partners with NDE1 and Dynactin To Orchestrate T Cell Focused Secretion.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meiotic nuclear oscillations in the fission yeast Schizosaccharomyces pombe are crucial for proper chromosome pairing and recombination. We report a mechanism of these oscillations on the basis of collective behavior of dynein motors linking the cell cortex and dynamic microtubules that extend from the spindle pole body in opposite directions. By combining quantitative live cell imaging and laser ablation with a theoretical description, we show that dynein dynamically redistributes in the cell in response to load forces, resulting in more dynein attached to the leading than to the trailing microtubules. The redistribution of motors introduces an asymmetry of motor forces pulling in opposite directions, leading to the generation of oscillations. Our work provides the first direct in vivo observation of self-organized dynamic dynein distributions, which, owing to the intrinsic motor properties, generate regular large-scale movements in the cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.