ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Increased Hox activity mimics the teratogenic effects of excess retinoic acid signaling.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 48 citations in OpenAlex.
- Long non-coding RNA gene polymorphisms and risk of recurrent pregnancy loss: a meta-analysis.Journal of assisted reproduction and genetics · 2026Review
- Association of Genetic Polymorphisms in Long Noncoding RNA HOTTIP with Risk of Idiopathic Recurrent Spontaneous Abortion.Biochemical genetics · 2024Review
- Single Cell Multimodal Analyses Reveal Epigenomic and Transcriptomic Basis for Birth Defects in Maternal Diabetes.Nature cardiovascular research · 2023Article
- Transcriptome-based prediction of drugs, inhibiting cardiomyogenesis in human induced pluripotent stem cells.Cell death discovery · 2023Article
- Dissecting mechanisms of chamber-specific cardiac differentiation and its perturbation following retinoic acid exposure.Development (Cambridge, England) · 2022Article
- Patterning of vertebrate cardiac progenitor fields by retinoic acid signaling.Genesis (New York, N.Y. : 2000) · 2021Review
- Atrial and Sinoatrial Node Development in the Zebrafish Heart.Journal of cardiovascular development and disease · 2021Review
- Elevated Hoxb5b Expands Vagal Neural Crest Pool and Blocks Enteric Neuronal Development in Zebrafish.Frontiers in cell and developmental biology · 2021Article
- An improved de novo assembling and polishing of Solea senegalensis transcriptome shed light on retinoic acid signalling in larvae.Scientific reports · 2020Article
- Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes.Journal of developmental biology · 2020Review
- Reiterative Mechanisms of Retinoic Acid Signaling during Vertebrate Heart Development.Journal of developmental biology · 2019Review
- HDAC1-mediated repression of the retinoic acid-responsive gene ripply3 promotes second heart field development.PLoS genetics · 2019Article
- Isotretinoin; A review on the Utilization Pattern in Pregnancy.Advanced pharmaceutical bulletin · 2018Review
- Carotenoid glycosides from cyanobacteria are teratogenic in the zebrafish (Danio rerio) embryo model.Chemosphere · 2017Article
- Hox Genes in Cardiovascular Development and Diseases.Journal of developmental biology · 2016Review
- Analysis of crosstalk between retinoic acid and sonic hedgehog pathways following ethanol exposure in embryonic zebrafish.Birth defects research. Part A, Clinical and molecular teratology · 2015Article
- Excessive feedback of Cyp26a1 promotes cell non-autonomous loss of retinoic acid signaling.Developmental biology · 2015Article
- Input overload: Contributions of retinoic acid signaling feedback mechanisms to heart development and teratogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Review
- Signaling through retinoic acid receptors in cardiac development: Doing the right things at the right times.Biochimica et biophysica acta · 2015Review
- Rdh10a Provides a Conserved Critical Step in the Synthesis of Retinoic Acid during Zebrafish Embryogenesis.PloS one · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Excess retinoic acid (RA) signaling can be teratogenic and result in cardiac birth defects, but the cellular and molecular origins of these defects are not well understood. Excessive RA signaling can completely eliminate heart formation in the zebrafish embryo. However, atrial and ventricular cells are differentially sensitive to more modest increases in RA signaling. Increased Hox activity, downstream of RA signaling, causes phenotypes similar to those resulting from excess RA. These results suggest that Hox activity mediates the differential effects of ectopic RA on atrial and ventricular cardiomyocytes and may underlie the teratogenic effects of RA on the heart.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.