ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Toward defining the phosphoproteome of Xenopus laevis embryos.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Transitions in the proteome and phospho-proteome during Xenopus laevis development.Developmental biology · 2025Article
- Phosphorylation Dynamics Dominate the Regulated Proteome during Early Xenopus Development.Scientific reports · 2017Article
- Tau-based fluorescent protein fusions to visualize microtubules.Cytoskeleton (Hoboken, N.J.) · 2017Article
- Identification of Maturation-Specific Proteins by Single-Cell Proteomics of Human Oocytes.Molecular & cellular proteomics : MCP · 2016Article
- Optimization and comparison of bottom-up proteomic sample preparation for early-stage Xenopus laevis embryos.Analytical and bioanalytical chemistry · 2016Article
- Exploring the phosphoproteome profiles during Xenopus egg activation by calcium stimulation using a fully automated phosphopeptide purification system.Journal of biochemistry · 2016Article
- Proteomics of Xenopus development.Molecular human reproduction · 2016Article
- On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development.Developmental cell · 2015Article
- Prediction of Functionally Important Phospho-Regulatory Events in Xenopus laevis Oocytes.PLoS computational biology · 2015Article
- Quantitative proteomics of Xenopus laevis embryos: expression kinetics of nearly 4000 proteins during early development.Scientific reports · 2014Article
- Molecular changes during egg activation.Current topics in developmental biology · 2013Review
- Embryonic poly(A)-binding protein (ePAB) phosphorylation is required for Xenopus oocyte maturation.The Biochemical journal · 2012Article
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Authors and funding
4 authors.
Funding
Abstract
Phosphorylation is universally used for controlling protein function, but knowledge of the phosphoproteome in vertebrate embryos has been limited. However, recent technical advances make it possible to define an organism's phosphoproteome at a more comprehensive level. Xenopus laevis offers established advantages for analyzing the regulation of protein function by phosphorylation. Functionally unbiased, comprehensive information about the Xenopus phosphoproteome would provide a powerful guide for future studies of phosphorylation in a developmental context. To this end, we performed a phosphoproteomic analysis of Xenopus oocytes, eggs, and embryos using recently developed mass spectrometry methods. We identified 1,441 phosphorylation sites present on 654 different Xenopus proteins, including hundreds of previously unknown phosphorylation sites. This approach identified several phosphorylation sites described in the literature and/or evolutionarily conserved in other organisms, validating the data's quality. These data will serve as a powerful resource for the exploration of phosphorylation and protein function within a developmental context. Developmental Dynamics 238:1433-1443, 2009. (c) 2009 Wiley-Liss, Inc.
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