ArticleInternational journal of emergency medicine2008
A treatment protocol including vasopressin and hydroxyethyl starch solution is associated with increased rate of return of spontaneous circulation in blunt trauma patients with pulseless electrical activity.
Article in International journal of emergency medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Vasopressin in hemorrhagic shock: a systematic review and meta-analysis of randomized animal trials.BioMed research international · 2014Pooled it
- Volume therapy for cardiac arrest: a systematic review and meta-analysis.Resuscitation plus · 2026Article
- Tapping on Pulseless Electrical Activity: An Opportunity for Improving Resuscitation Outcomes?Journal of the American Heart Association · 2021Article
- Prehospital intravenous epinephrine may boost survival of patients with traumatic cardiac arrest: a retrospective cohort study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2015Article
- Comment on Grmec et al.: a treatment protocol including vasopressin and hydroxyethyl starch solution is associated with increased rate of return of spontaneous circulation in blunt trauma patients with pulseless electrical activity.International journal of emergency medicine · 2009Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurvival after cardiopulmonary resuscitation (CPR) using standard vasopressor therapy is disappointing. Vasopressin is a potent vasopressor that could become a useful therapeutic alternative in the treatment of cardiac arrest.
aimsThe aim of this prehospital prospective cohort study was to assess the influence of treatment with vasopressin and hydroxyethyl starch solution (HHS) on outcome in resuscitated blunt trauma patients with pulseless electrical activity (PEA) cardiac arrest.
methodsTwo treatment groups of resuscitated trauma patients in cardiac arrest were compared: in the epinephrine group patients received epinephrine 1 mg IV every 3 min only; in the vasopressin group patients first received hypertonic HHS and arginine vasopressin 40 units IV only or followed by epinephrine 1 mg every 3 min until cessation of CPR. Medical trauma care was provided according to advanced trauma life support (ATLS) guidelines.
resultsThe study included 31 patients and there were no significant demographic or clinical differences between the treatment groups. Significantly more circulatory restorations [11/13 (85%) vs 3/18 (17%); P < 0.01] and better 24-h survival rates [8/13 (62%) vs 2/18 (11%); P = 0.001] were observed in the vasopressin group. Average mean arterial pressure (100.4 +/- 11.4 mmHg vs 80.3 +/- 12.4 mmHg) and final end-tidal partial pressure of carbon dioxide (PETCO(2)) at admission (4.5 +/- 0.9 kPa vs 2.8 +/- 0.4 kPa) were also higher in the vasopressin group.
conclusionOur results suggest that victims of severe blunt trauma with PEA should be initially treated with vasopressin in combination with HHS volume resuscitation followed by standard resuscitation therapy and other procedures when appropriate. Vasopressin might be potentially lifesaving in blunt trauma cardiac arrest compared to standard treatment with epinephrine.
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Registered trials
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