ArticleNeurotoxicity research2009
Diabetic hyperglycemia aggravates seizures and status epilepticus-induced hippocampal damage.
Article in Neurotoxicity research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Type 2 Diabetes Mellitus Exacerbates Brain Injury AfterBrain sciences · 2025Article
- Role of Diabetes and its metabolic pathways in Epilepsy: An insight to various target approaches.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Evaluating the Incidence of Seizures and Its Relationship With Blood Glucose Levels in Tramadol Poisoning Patients Admitted to Imam Reza Hospital in Mashhad (Iran) From 2019 to 2020.Journal of toxicology · 2025Article
- Type 2 diabetes mellitus facilitates status epilepticus in adult rats: Seizure severity, neurodegeneration, and oxidative stress.Epilepsia open · 2024Article
- Cognitive comorbidities in the rat pilocarpine model of epilepsy.Frontiers in neurology · 2024Article
- The Discordance between Network Excitability and Cognitive Performance Following Vigabatrin Treatment during Epileptogenesis.Life (Basel, Switzerland) · 2021Article
- Role of Modulation of Hippocampal Glucose Following Pilocarpine-Induced Status Epilepticus.Molecular neurobiology · 2021Article
- An Open Pilot Study of the Effect and Tolerability of Add-On Multivitamin Therapy in Patients with Intractable Focal Epilepsy.Nutrients · 2020Article
- Downregulation of Astrocytic Kir4.1 Potassium Channels Is Associated with Hippocampal Neuronal Hyperexcitability in Type 2 Diabetic Mice.Brain sciences · 2020Article
- The Protective Role of Peroxisome Proliferator-Activated Receptor-Gamma in Seizure and Neuronal Excitotoxicity.Molecular neurobiology · 2019Article
- Sodium Metabisulfite: Effects on Ionic Currents and Excitotoxicity.Neurotoxicity research · 2018Article
- Factors associated with poor discharge status in patients with status epilepticus at Khon Kaen Hospital.Neuropsychiatric disease and treatment · 2015Article
- Pregabalin attenuates excitotoxicity in diabetes.PloS one · 2013Article
- The effects of glycemic control on seizures and seizure-induced excitotoxic cell death.BMC neuroscience · 2012Article
- Effects of infantile repeated hyperglycemia on neuronal density of hippocampus and pentylentetrazol induced convulsions in male wistar rats.Iranian journal of basic medical sciences · 2012Article
- Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability.Psychopharmacology · 2012Article
- Risk factors for complications of drug-induced seizures.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2011Article
- Diazoxide reduces status epilepticus neuron damage in diabetes.Neurotoxicity research · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epileptic seizures in diabetic hyperglycemia (DH) are not uncommon. This study aimed to determine the acute behavioral, pathological, and electrophysiological effects of status epilepticus (SE) on diabetic animals. Adult male Sprague-Dawley rats were first divided into groups with and without streptozotocin (STZ)-induced diabetes, and then into treatment groups given a normal saline (NS) (STZ-only and NS-only) or a lithium-pilocarpine injection to induce status epilepticus (STZ + SE and NS + SE). Seizure susceptibility, severity, and mortality were evaluated. Serial Morris water maze test and hippocampal histopathology results were examined before and 24 h after SE. Tetanic stimulation-induced long-term potentiation (LTP) in a hippocampal slice was recorded in a multi-electrode dish system. We also used a simulation model to evaluate intracellular adenosine triphosphate (ATP) and neuroexcitability. The STZ + SE group had a significantly higher percentage of severe seizures and SE-related death and worse learning and memory performances than the other three groups 24 h after SE. The STZ + SE group, and then the NS + SE group, showed the most severe neuronal loss and mossy fiber sprouting in the hippocampal CA3 area. In addition, LTP was markedly attenuated in the STZ + SE group, and then the NS + SE group. In the simulation, increased intracellular ATP concentration promoted action potential firing. This finding that rats with DH had more brain damage after SE than rats without diabetes suggests the importance of intensively treating hyperglycemia and seizures in diabetic patients with epilepsy.
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