ArticleBritish journal of cancer2009
High expression of tumour-associated trypsin inhibitor correlates with liver metastasis and poor prognosis in colorectal cancer.
Article in British journal of cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 62 citations in OpenAlex.
- Overcoming the Challenge: A Comprehensive Review of Neoadjuvant Treatment Resistance in Rectal Cancer.Journal of gastrointestinal cancer · 2025Review
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- Identification and Characterization of a Trypsin Inhibitor from Fagopyrum tataricumSeeds.Applied biochemistry and biotechnology · 2024Article
- Deepfake Histologic Images for Enhancing Digital Pathology.Laboratory investigation; a journal of technical methods and pathology · 2023Article
- Article
- Colon Cancer Grading Using Infrared Spectroscopic Imaging-Based Deep Learning.Applied spectroscopy · 2022Article
- Nitrogen-doped carbon quantum dots fabricated from cellulolytic enzyme lignin and its application to the determination of cytochrome c and trypsin.Analytical and bioanalytical chemistry · 2021Article
- Article
- INFORM: INFrared-based ORganizational Measurements of tumor and its microenvironment to predict patient survival.Science advances · 2021Article
- Identification of diagnostic upper gastrointestinal cancer tissue type-specific urinary biomarkers.Biomedical reports · 2019Article
- Hepatitis B Virus X Protein-Induced Serine Protease Inhibitor Kazal Type 1 Is Associated with the Progression of HBV-Related Diseases.BioMed research international · 2019Article
- SPINK1 promotes cell growth and metastasis of lung adenocarcinoma and acts as a novel prognostic biomarker.BMB reports · 2018Article
- Monitoring the treatment outcome in endometrial cancer patients by CEA and TATI.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor receptor expression in colorectal cancer.Journal of translational medicine · 2016Article
- Serine Protease Inhibitor Kazal Type 1 (SPINK1) Promotes Proliferation of Colorectal Cancer Through the Epidermal Growth Factor as a Prognostic Marker.Pathology oncology research : POR · 2015Article
- SPINK1 promotes colorectal cancer progression by downregulating Metallothioneins expression.Oncogenesis · 2015Article
- Cbl-b accelerates trypsin-induced cell detachment through ubiquitination and degradation of proline-rich tyrosine kinase 2.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Application of an electrochemical immunosensor with a MWCNT/PDAA modified electrode for detection of serum trypsin.Sensors (Basel, Switzerland) · 2014Article
- Article
- Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer.The Journal of pathology · 2013Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased expression of tumour-associated trypsin inhibitor (TATI) in tumour tissue and/or serum has been associated with poor survival in various cancer forms. Moreover, a proinvasive function of TATI has been shown in colon cancer cell lines. In this study, we have examined the prognostic significance of tumour-specific TATI expression in colorectal cancer, assessed by immunohistochemistry (IHC) on tissue microarrays (TMAs) with tumour specimens from two independent patient cohorts. Kaplan-Meier analysis and Cox proportional hazards modelling were used to estimate time to recurrence, disease-free survival and overall survival. In both cohorts, a high (>50% of tumour cells) TATI expression was an independent predictor of a significantly shorter overall survival. In cohort II, in multivariate analysis including age, gender, disease stage, differentiation grade, vascular invasion and carcinoembryonal antigen (CEA), high TATI expression was associated with a significantly decreased overall survival (HR=1.82; 95% CI=1.19-2.79) and disease-free survival (HR=1.56; 95% CI=1.05-2.32) in curatively treated patients. Moreover, there was an increased risk for liver metastasis in both cohorts that remained significant in multivariate analysis in cohort II (HR=2.85; 95% CI=1.43-5.66). In conclusion, high TATI expression is associated with liver metastasis and is an independent predictor of poor prognosis in patients with colorectal cancer.
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