ArticleCritical care medicine2009
Lung injury after hemorrhage is age dependent: role of peroxisome proliferator-activated receptor gamma.
Article in Critical care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Children with open tibial fractures show significantly lower infection rates than adults: clinical comparative study.International orthopaedics · 2019Article
- Metformin ameliorates gender-and age-dependent hemodynamic instability and myocardial injury in murine hemorrhagic shock.Biochimica et biophysica acta. Molecular basis of disease · 2017Article
- Age-Dependent Changes in AMPK Metabolic Pathways in the Lung in a Mouse Model of Hemorrhagic Shock.American journal of respiratory cell and molecular biology · 2017Article
- Maraviroc-Mediated Lung Protection following Trauma-Hemorrhagic Shock.BioMed research international · 2016Article
- Aging and injury: alterations in cellular energetics and organ function.Aging and disease · 2014Review
- Interleukin-6 as inflammatory marker referring to multiple organ dysfunction syndrome in severely injured children.Scandinavian journal of trauma, resuscitation and emergency medicine · 2014Article
- Effects of the PPAR-β/δ agonist GW0742 during resuscitated porcine septic shock.Intensive care medicine experimental · 2013Article
- Maraviroc attenuates trauma-hemorrhage-induced hepatic injury through PPAR gamma-dependent pathway in rats.PloS one · 2013Article
- Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating Sirt1.Molecular medicine (Cambridge, Mass.) · 2012Article
- Influence of aging and hemorrhage injury on Sirt1 expression: possible role of myc-Sirt1 regulation in mitochondrial function.Biochimica et biophysica acta · 2011Article
- C-peptide, a novel inhibitor of lung inflammation following hemorrhagic shock.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor κB pathway.Shock (Augusta, Ga.) · 2011Article
- The host response to sepsis and developmental impact.Pediatrics · 2010Review
- Liver apoptosis is age dependent and is reduced by activation of peroxisome proliferator-activated receptor-gamma in hemorrhagic shock.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe incidence of multiple organ failure in pediatric trauma victims is lower than in the adult population. However, the molecular mechanisms are not yet defined. We investigated whether the pathophysiologic characteristics of hemorrhage-induced lung injury may be age dependent and may be regulated by the peroxisome proliferator-activated receptor gamma (PPARgamma).
designProspective, laboratory investigation that used an established rodent model of hemorrhagic shock.
settingUniversity hospital laboratory. SUBJECTS: Young (n = 67; 3-5 months old) and mature (n = 66; 11-13 months old) male rats.
interventionsHemorrhagic shock was induced in young and mature rats by withdrawing blood to a mean arterial blood pressure of 50 mm Hg. After 3 hours, rats were rapidly resuscitated by infusing the shed blood and killed 3 hours thereafter. MEASUREMENTS AND MAIN
resultsIn young rats, lung injury was characterized by accumulation of red cells and neutrophils at the end of the resuscitation period; on Western blot analysis, lung expression of intercellular adhesion molecule-1 was increased. In contrast, the severity of lung injury was more pronounced in mature rats. Lung myeloperoxidase activity and expression of constitutive and inducible intercellular adhesion molecule-1 was significantly higher in mature rats compared with young rats. Mature rats also had higher plasma levels of cytokines and chemokines compared with young rats. This heightened inflammation was associated with higher degree of activation of nuclear factor-kappaB and down-regulation of PPARgamma and heat shock factor-1 in the lung of mature rats compared with young rats. Treatment with the PPARgamma ligand, the cyclopentenone prostaglandin 15-deoxy-Delta-prostaglandin J2, ameliorated lung injury in young, but not in mature animals.
conclusionsLung injury after severe hemorrhage is age dependent and may be secondary to a diverse regulation of PPARgamma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.