ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2009
Genetic polymorphisms in the catechol estrogen metabolism pathway and breast cancer risk.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 6 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 6 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Meta-analysis of genetic polymorphisms in xenobiotic metabolizing enzymes and their association with breast cancer risk.Journal of genetics · 2018Pooled it
- CYP1A1 and GSTP1 gene variations in breast cancer: a systematic review and case-control study.Familial cancer · 2016Pooled it
- Association between the CYP1B1 polymorphisms and risk of cancer: a meta-analysis.Molecular genetics and genomics : MGG · 2015Pooled it
- A meta-analysis of the association of glutathione S-transferase P1 gene polymorphism with the susceptibility of breast cancer.Molecular biology reports · 2013Pooled it
- Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis.Diagnostic pathology · 2012Pooled it
- Association between the COMT Val158Met polymorphism and breast cancer risk: a meta-analysis of 30,199 cases and 38,922 controls.Molecular biology reports · 2012Pooled it
- Trial
- Role of Genetic Variation in Cytochromes P450 in Breast Cancer Prognosis and Therapy Response.International journal of molecular sciences · 2021Trial
- The MiBlend Randomized Trial: Investigating Genetic Polymorphisms in Personalized Responses to Fruit and Vegetable Interventions for Chronic Disease Prevention.Antioxidants (Basel, Switzerland) · 2025Article
- Detection ofJournal of clinical medicine · 2023Article
- Article
- Discovery of breast cancer risk genes and establishment of a prediction model based on estrogen metabolism regulation.BMC cancer · 2021Article
- Interaction between dietary acrylamide intake and genetic variants for estrogen receptor-positive breast cancer risk.European journal of nutrition · 2019Article
- Genetic polymorphisms in estrogen-related genes and the risk of breast cancer among Han Chinese women.International journal of molecular sciences · 2015Article
- Estrogen metabolism and breast cancer.Cancer letters · 2015Review
- Association between the COMT Val158Met polymorphism and risk of cancer: evidence from 99 case-control studies.OncoTargets and therapy · 2015Article
- GSTP1 methylation and polymorphism increase the risk of breast cancer and the effects of diet and lifestyle in breast cancer patients.Experimental and therapeutic medicine · 2012Article
- Polymorphisms in hormone metabolism and growth factor genes and mammographic density in Norwegian postmenopausal hormone therapy users and non-users.Breast cancer research : BCR · 2012Article
- Estrogen-related genes and their contribution to racial differences in breast cancer risk.Cancer causes & control : CCC · 2012Article
- A polymorphism in the nuclear receptor coactivator 7 gene and breast cancer susceptibility.Oncology letters · 2012Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThis study investigated whether single nucleotide polymorphisms (SNP) in genes within the catechol estrogen metabolism pathway altered the risk of breast cancer alone or in combination, as well as whether menopausal hormone therapy modified the effect of these SNPs on breast cancer risk.
methodsIn a population-based case-control study of breast cancer, 891 cases and 878 controls were genotyped for six functional SNPs in the COMT, CYP1B1, GSTM1, GSTP1, and GSTT1 genes.
resultsWomen homozygous with the T allele in CYP1B1*2 (Ser(119); rs1056827) were at 1.69 (95% confidence interval, 1.17-2.46) times the risk of women homozygous with the G allele; women homozygous with the G allele in GSTP1 (Val(105); rs1695) were at 0.73 (95% confidence interval, 0.54-0.99) times the risk of breast cancer compared with women homozygous with the A allele. No other SNPs tested were associated with breast cancer to any appreciable degree. Potential gene-gene and gene-hormone therapy interactions were investigated.
conclusionWith the exception of GSTP1 and possibly CYP1B1*2, our findings do not provide support for the role of genetic variation in the catechol estrogen metabolism pathway and breast cancer risk in postmenopausal women.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.