ArticleMicrobiology (Reading, England)2009
Identification of novel LPXTG-linked surface proteins from Streptococcus gordonii.
Article in Microbiology (Reading, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Identification of a conserved GNAT-family lysine acetyltransferase inJournal of bacteriology · 2026Article
- Structural and functional insights of sortases and their interactions with antivirulence compounds.Current research in structural biology · 2024Review
- Three-Dimensional Oral Mucosal Equivalents as Models for Transmucosal Drug Permeation Studies.Pharmaceutics · 2023Article
- Streptococcus gordonii Poised for Glycan Feeding through a MUC5B-Discriminating, Lipoteichoic Acid-Mediated Outside-In Signaling Circuit.Journal of bacteriology · 2022Article
- Polymicrobial synergy stimulates Porphyromonas gingivalis survival and gingipain expression in a multi-species subgingival community.BMC oral health · 2021Article
- The divergent roles of sortase in the biology of Gram-positive bacteria.Cell surface (Amsterdam, Netherlands) · 2021Review
- Proteomic response inJournal of oral microbiology · 2021Article
- Uncovering Roles of Streptococcus gordonii SrtA-Processed Proteins in the Biofilm Lifestyle.Journal of bacteriology · 2020Article
- Review
- Intracellular Ser/Thr/Tyr phosphoproteome of the oral commensal Streptococcus gordonii DL1.BMC microbiology · 2020Article
- Streptococcus gordonii Type I Lipoteichoic Acid Contributes to Surface Protein Biogenesis.mSphere · 2019Article
- An intramembrane sensory circuit monitors sortase A-mediated processing of streptococcal adhesins.Science signaling · 2019Article
- Effect of SrtA on Interspecies Adherence of Oral Bacteria.Current medical science · 2018Article
- Transcriptome-wide responses of adult melon thrips (Thrips palmi) associated with capsicum chlorosis virus infection.PloS one · 2018Article
- Identification of new Corynebacterium pseudotuberculosis antigens by immunoscreening of gene expression library.BMC microbiology · 2017Article
- The proteins of Fusobacterium spp. involved in hydrogen sulfide production from L-cysteine.BMC microbiology · 2017Article
- Biofilm-specific extracellular matrix proteins of nontypeable Haemophilus influenzae.Pathogens and disease · 2014Article
- Surface-associated MUC5B mucins promote protease activity in Lactobacillus fermentum biofilms.BMC oral health · 2013Article
- Salivary pellicles on titanium and their effect on metabolic activity in Streptococcus oralis.BMC oral health · 2013Article
- Structural and functional analysis of the N-terminal domain of the Streptococcus gordonii adhesin Sgo0707.PloS one · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Surface adhesion plays an essential part in the survival of the commensal organism Streptococcus gordonii in the oral cavity as well as during opportunistic infections such as endocarditis. At least two types of cell surface protein involved in adhesion are found on the surface of Gram-positive bacteria: those anchored via an LPXTG motif by the enzyme sortase A (SrtA) and those associated with the cell surface by, as yet, unknown mechanisms. In srtA(-) mutants, LPXTG-containing proteins have been shown to be released rather than cross-linked to the cell wall. We have therefore used 2D gel electrophoresis of released proteins from an srtA(-) mutant as well as the wild-type strain, followed by peptide identification by MS, to identify a set of novel proteins predicted to be present on the surface of S. gordonii DL1. This includes two large LPXTG-linked proteins (SGO_0707 and SGO_1487), which both contain tandemly repeated sequences similar to those present in known fibrillar adhesins. A 5'-nucleotidase and a protein with a putative collagen-binding domain, both containing LPXTG motifs, were also identified. Anchorless proteins with known chaperone, stress response and elongation factor functions, apparently responsible for bacterial binding to keratinocytes and saliva-coated surfaces in the absence of the LPXTG-linked adhesins, were also associated with the cell surface. These data reveal a range of proteins to be present on the S. gordonii DL1 cell surface, the expression of which plays an important role in adhesion to epithelia and which represent likely candidates for novel virulence factors in S. gordonii.
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