ReviewThe Journal of biological chemistry2009
State-stabilizing Interactions in Bacterial Mechanosensitive Channel Gating and Adaptation.
Review in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Lipid Regulation of Mechanosensitive Ion Channels.International journal of molecular sciences · 2026Review
- Pseudomonas doesn't mind a dunking.The Journal of general physiology · 2017Article
- The role of lipids in mechanosensation.Nature structural & molecular biology · 2015Article
- The primary cilium is a self-adaptable, integrating nexus for mechanical stimuli and cellular signaling.Biology open · 2015Article
- Unconventional mechanics of lipid membranes: a potential role for mechanotransduction of hair cell stereocilia.Biophysical journal · 2015Article
- Article
- The MscS and MscL families of mechanosensitive channels act as microbial emergency release valves.Journal of bacteriology · 2012Review
- Bacterial mechanosensitive channels--MscS: evolution's solution to creating sensitivity in function.Annual review of biophysics · 2012Review
- Mechanism of function of viral channel proteins and implications for drug development.International review of cell and molecular biology · 2012Review
- Luminescence resonance energy transfer in the cytoplasm of live Escherichia coli cells.Biochemistry · 2011Article
- Toward understanding protocell mechanosensation.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2011Review
- Genetic screen for potassium leaky small mechanosensitive channels (MscS) in Escherichia coli: recognition of cytoplasmic β domain as a new gating element.The Journal of biological chemistry · 2011Article
- Structures of membrane proteins.Quarterly reviews of biophysics · 2010Review
- CFTR is a mechanosensitive anion channel: a real stretch?Cellscience · 2010Article
- Curvature generation and pressure profile modulation in membrane by lysolipids: insights from coarse-grained simulations.Biophysical journal · 2009Article
- Article
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Authors and funding
2 authors.
Funding
Abstract
We outline several principles that we believe define the gating of two bacterial mechanosensitive channels, MscL and MscS. Serving as turgor regulators in bacteria and other walled cells, these molecules are tangible models for studying conformational transitions in membrane proteins driven directly by membrane tension. MscL, a compact pentamer, reversibly opens a gigantic 30-A pore at near-lytic tensions. MscS, a heptameric complex, exhibits transient activation of a smaller pore at moderate tensions, thereby entering a tension-insensitive inactivated state. By comparing the structures and predicted transitions in these channels, we concluded that opening is commonly achieved through tilting and outward motion of the pore-lining helices, which is kinetically limited by hydration of the pore. The intricate adaptive behavior in MscS appears to depend on specific interhelical associations and the flexibility of the pore-lining helices. We discuss physical factors that may direct the transitions and stabilize main functional states in these channels.
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