ArticleThe Journal of steroid biochemistry and molecular biology2009
Progesterone receptor A-regulated gene expression in mammary organoid cultures.
Article in The Journal of steroid biochemistry and molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Exploring the interaction between extracellular matrix components in a 3D organoid disease model to replicate the pathophysiology of breast cancer.Journal of experimental & clinical cancer research : CR · 2023Review
- Low-Dose Sodium Salicylate Promotes Ovulation by Regulating Steroids via CYP17A1.International journal of molecular sciences · 2023Article
- Unique Transcriptomic Changes Underlie Hormonal Interactions During Mammary Histomorphogenesis in Female Pigs.Endocrinology · 2022Article
- Effect of acetate, β-hydroxybutyrate and their interaction on lipogenic gene expression, triglyceride contents and lipid droplet formation in dairy cow mammary epithelial cells.In vitro cellular & developmental biology. Animal · 2021Article
- Estimated Number of Lifetime Ovulatory Years and Its Determinants in Relation to Levels of Circulating Inflammatory Biomarkers.American journal of epidemiology · 2020Article
- Transcriptomic and computational analysis identified LPA metabolism, KLHL14 and KCNE3 as novel regulators of Epithelial-Mesenchymal Transition.Scientific reports · 2020Article
- Ovulation: Parallels With Inflammatory Processes.Endocrine reviews · 2019Review
- C/EBPβ LIP and c-Jun synergize to regulate expression of the murine progesterone receptor.Molecular and cellular endocrinology · 2018Article
- Progesterone-induced activation of membrane-bound progesterone receptors in murine macrophage cells.The Journal of endocrinology · 2015Article
- The role of ovarian sex steroids in metabolic homeostasis, obesity, and postmenopausal breast cancer: molecular mechanisms and therapeutic implications.BioMed research international · 2015Review
- Epidermal growth factor receptor (EGFR) signaling is a key mediator of hormone-induced leukocyte infiltration in the pubertal female mammary gland.Endocrinology · 2014Article
- Leucyl-tRNA synthetase regulates lactation and cell proliferation via mTOR signaling in dairy cow mammary epithelial cells.International journal of molecular sciences · 2014Article
- Article
- Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Proteomic and functional analyses reveal MAPK1 regulates milk protein synthesis.Molecules (Basel, Switzerland) · 2012Article
- A potential role of progestin-induced laminin-5/α6-integrin signaling in the formation of side branches in the mammary gland.Endocrinology · 2012Article
- Progesterone receptors, their isoforms and progesterone regulated transcription.Molecular and cellular endocrinology · 2012Review
- Progesterone regulation of stem and progenitor cells in normal and malignant breast.Molecular and cellular endocrinology · 2012Review
- MiR-126-3p regulates progesterone receptors and involves development and lactation of mouse mammary gland.Molecular and cellular biochemistry · 2011Article
- Leukocytes in mammary development and cancer.Cold Spring Harbor perspectives in biology · 2011Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Progesterone, through the progesterone receptor (PR), promotes development of the normal mammary gland and is implicated in the etiology of breast cancer. We identified PRA-regulated genes by microarray analysis of cultured epithelial organoids derived from pubertal and adult mouse mammary glands, developmental stages with differing progesterone responsiveness. Microarray analysis showed significant progestin (R5020)-regulation of 162 genes in pubertal organoids and 104 genes in adult organoids, with 68 genes regulated at both developmental stages. Greater induction of receptor activator of NFkappaB ligand and calcitonin expression was observed in adult organoids, suggesting possible roles in the differential progesterone responsiveness of the adult and pubertal mammary glands. Analysis of the R5020-responsive transcriptome revealed several enriched biological processes including cell adhesion, immune response, and survival. R5020 both induced Agtr1 and potentiated angiotensin II-stimulated proliferation, highlighting the functional significance of the latter process. Striking up-regulation of genes involved in innate immunity processes included the leukocyte chemoattractants serum amyloid A1, 2 and 3 (Saa1, 2, 3). In vivo analysis revealed that progesterone treatment increased SAA1 protein expression and leukocyte density in mammary gland regions undergoing epithelial expansion. These studies reveal novel targets of PRA in mammary epithelial cells and novel linkages of progesterone action during mammary gland development.
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