ArticleBiophysical journal2009
Free energies of molecular bound states in lipid bilayers: lethal concentrations of antimicrobial peptides.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 72 citations in OpenAlex.
- The Role of Flexibility in the Bioactivity of Short α-Helical Antimicrobial Peptides.Antibiotics (Basel, Switzerland) · 2025Review
- Melittin can permeabilize membranes via large transient pores.Nature communications · 2024Article
- The Role of Key Amino Acids in the Antimicrobial Mechanism of a Bacteriocin Model Revealed by Molecular Simulations.Journal of chemical information and modeling · 2021Article
- Latest developments on the mechanism of action of membrane disrupting peptides.Biophysics reports · 2021Article
- Functionalization of hydrophobic surfaces with antimicrobial peptides immobilized on a bio-interfactant layer.RSC advances · 2019Article
- Toward building a physical model for membrane selectivity of antimicrobial peptides: making a quantitative sense of the selectivity.Soft matter · 2019Article
- The role of membrane tension in the action of antimicrobial peptides and cell-penetrating peptides in biomembranes.Biophysical reviews · 2019Review
- Antimicrobial Photodynamic therapy enhanced by the peptide aurein 1.2.Scientific reports · 2018Article
- Curcumin-loaded nanoliposomes linked to homing peptides for integrin targeting and neuropilin-1-mediated internalization.Pharmaceutical biology · 2017Article
- Kinetic Defects Induced by Melittin in Model Lipid Membranes: A Solution Atomic Force Microscopy Study.The journal of physical chemistry. B · 2016Article
- New role for human α-defensin 5 in the fight against hypervirulent Clostridium difficile strains.Infection and immunity · 2015Article
- Physical properties of Escherichia coli spheroplast membranes.Biophysical journal · 2014Article
- Process of inducing pores in membranes by melittin.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Current fluctuation analysis of the PopB and PopD translocon components of the Pseudomonas aeruginosa type III secretion system.Biophysical journal · 2013Article
- Inclusion of lateral pressure/curvature stress effects in implicit membrane models.Biophysical journal · 2013Article
- How type II diabetes-related islet amyloid polypeptide damages lipid bilayers.Biophysical journal · 2012Article
- Article
- Bioactivity and the first transmission electron microscopy immunogold studies of short de novo-designed antimicrobial peptides.Antimicrobial agents and chemotherapy · 2011Article
- Transmembrane pores formed by human antimicrobial peptide LL-37.Biophysical journal · 2011Article
- A lipocentric view of peptide-induced pores.European biophysics journal : EBJ · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The lipid matrix, or the lipid bilayer, of cell membranes is a natural binding site for amphipathic molecules, including antimicrobial peptides, pore-forming proteins, and many drugs. The unique property of pore-forming antimicrobial peptides is that they exhibit a threshold concentration (called the lethal concentration or the minimum inhibitory concentration) for activity, below which no effect is seen. Without this property, antimicrobial peptides would not be effective self-defense weapons, because they would have harmed all cells at any concentration. The question is what gives rise to this unique property? This study provides a free energy description for the origin of a threshold concentration. The same free energy applied differently also explains the binding of drugs that shows no threshold concentrations. The idea is compared with theories of micellar solutions that require a large oligomer size (n 15) to achieve a threshold concentration. The elasticity of lipid bilayers makes the phenomena in membranes different. The majority of antimicrobial peptides have a large negative binding energy to the bilayer interface, but the binding causes an expansion in the membrane area, or equivalently a thinning in the membrane thickness. This elastic energy of membrane thinning elevates the energy level of interfacial binding with the peptide concentration, hence gives rise to a threshold concentration for forming pores containing as few as four peptides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.