ArticleBiophysical journal2009
Transmembrane helical domain of the cannabinoid CB1 receptor.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Structural and functional insights into the G protein-coupled receptors: CB1 and CB2.Biochemical Society transactions · 2023Review
- Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.Chemical reviews · 2019Review
- Effect of Temporal Expression of Integral Membrane Proteins by Baculovirus Expression Vector System.Molecular biotechnology · 2018Article
- Relax, Cool Down and Scaffold: How to Restore Surface Expression of Folding-Deficient Mutant GPCRs and SLC6 Transporters.International journal of molecular sciences · 2017Review
- Molecular basis of cannabinoid CB1 receptor coupling to the G protein heterotrimer Gαiβγ: identification of key CB1 contacts with the C-terminal helix α5 of Gαi.The Journal of biological chemistry · 2013Article
- Molecular basis for dramatic changes in cannabinoid CB1 G protein-coupled receptor activation upon single and double point mutations.Protein science : a publication of the Protein Society · 2013Article
- IRAK4 and TLR3 Sequence Variants may Alter Breast Cancer Risk among African-American Women.Frontiers in immunology · 2013Article
- In silico investigation of interactions between human cannabinoid receptor-1 and its antagonists.Journal of molecular modeling · 2012Article
- Nicotine-like effects of the neonicotinoid insecticides acetamiprid and imidacloprid on cerebellar neurons from neonatal rats.PloS one · 2012Article
- Multiple functions of endocannabinoid signaling in the brain.Annual review of neuroscience · 2012Review
- Identification of essential cannabinoid-binding domains: structural insights into early dynamic events in receptor activation.The Journal of biological chemistry · 2011Article
- Modeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β 2 AR.Journal of molecular modeling · 2011Article
- The cannabinoid type-1 receptor carboxyl-terminus, more than just a tail.Journal of neurochemistry · 2011Review
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- Understanding functional residues of the cannabinoid CB1.Current topics in medicinal chemistry · 2010Review
- Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown.Current medicinal chemistry · 2010Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Brain cannabinoid (CB(1)) receptors are G-protein coupled receptors and belong to the rhodopsin-like subfamily. A homology model of the inactive state of the CB(1) receptor was constructed using the x-ray structure of beta(2)-adrenergic receptor (beta(2)AR) as the template. We used 105 ns duration molecular-dynamics simulations of the CB(1) receptor embedded in a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) bilayer to gain some insight into the structure and function of the CB(1) receptor. As judged from the root mean-square deviations combined with the detailed structural analyses, the helical bundle of the CB(1) receptor appears to be fully converged in 50 ns of the simulation. The results reveal that the helical bundle structure of the CB(1) receptor maintains a topology quite similar to the x-ray structures of G-protein coupled receptors overall. It is also revealed that the CB(1) receptor is stabilized by the formation of extensive, water-mediated H-bond networks, aromatic stacking interactions, and receptor-lipid interactions within the helical core region. It is likely that these interactions, which are often specific to functional motifs, including the S(N)LAxAD, D(E)RY, CWxP, and NPxxY motifs, are the molecular constraints imposed on the inactive state of the CB(1) receptor. It appears that disruption of these specific interactions is necessary to release the molecular constraints to achieve a conformational change of the receptor suitable for G-protein activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.