ArticleBiophysical journal2009
Extracellular space attenuates the effect of gap junctional remodeling on wave propagation: a computational study.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Evaluation of Tyrosine Kinase Inhibitors Loaded Injectable Hydrogels for Improving Connexin43 Gap Junction Intercellular Communication.ACS applied materials & interfaces · 2024Article
- Diazoxide Improves Mitochondrial Connexin 43 Expression in a Mouse Model of Doxorubicin-Induced Cardiotoxicity.International journal of molecular sciences · 2018Article
- CaFrontiers in physiology · 2018Article
- Modeling the Electrophysiological Properties of the Infarct Border Zone.Frontiers in physiology · 2018Review
- Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.Pharmacological reviews · 2017Review
- Role of CAPE on cardiomyocyte protection via connexin 43 regulation under hypoxia.International journal of medical sciences · 2016Article
- Dynamics of propagation of premature impulses in structurally remodeled infarcted myocardium: a computational analysis.Frontiers in physiology · 2014Article
- Microscopic variations in interstitial and intracellular structure modulate the distribution of conduction delays and block in cardiac tissue with source-load mismatch.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2012Article
- Effect of heterogeneities in the cellular microstructure on propagation of the cardiac action potential.Medical & biological engineering & computing · 2012Article
- Interstitial volume modulates the conduction velocity-gap junction relationship.American journal of physiology. Heart and circulatory physiology · 2012Article
- A simulation study of cellular hypertrophy and connexin lateralization in cardiac tissue.Biophysical journal · 2010Article
- A biophysical model for cardiac microimpedance measurements.American journal of physiology. Heart and circulatory physiology · 2010Article
- Increased interstitial loading reduces the effect of microstructural variations in cardiac tissue.American journal of physiology. Heart and circulatory physiology · 2010Article
- Oxidized calmodulin kinase II regulates conduction following myocardial infarction: a computational analysis.PLoS computational biology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
unlabelledIonic channels and gap junctions are remodeled in cells from the 5-day epicardial border zone (EBZ) of the healing canine infarct. The main objective of the study was to determine the effect of gap junctional conductance (Gj) remodeling and Cx43 redistribution to the lateral membrane on conduction velocity (theta) and anisotropic ratio, and how gap junctional remodeling is modulated by the extracellular space. We first implemented subcellular monodomain and two-domain computer models of normal epicardium (NZ) to understand how extracellular space modulates the relationship between Gj and theta in NZ. We found that the extracellular space flattens the Gj-theta relationship, thus theta becomes less sensitive to changes in Gj. We then investigated the functional consequences of Gj remodeling and Cx43 distribution in subcellular computer models of cells of the outer pathway (IZo) and central pathway (IZc) of reentrant circuits. In IZo cells, side-to-side (transverse) Gj is 10% the value in NZ cells. Such Gj remodeling causes a 45% decrease in transverse theta (theta(T)). Inclusion of an extracellular space reduces the decrease in theta(T) to 31%. In IZc cells, Cx43 redistribution along the lateral membrane results in a 29% increase in theta(T). That increase in theta(T) is a consequence of the decrease in access resistance to the Cx43 plaques that occur with the Cx43 redistribution. Extracellular space reduces the increase in theta(T) to 10%. IN
conclusion1), The extracellular space included in normal epicardial simulations flattens the Gj-theta relationship with theta becoming less sensitive to changes in Gj. 2), The extracellular space attenuates the effects of gap junction epicardial border zone remodeling (i.e., Gj reduction and Cx43 lateralization) on theta(T).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.