ArticleMolecular oncology2008
TIMP-1 expression in human colorectal cancer is associated with TGF-B1, LOXL2, INHBA1, TNF-AIP6 and TIMP-2 transcript profiles.
Article in Molecular oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- Biological function and potential application of PANoptosis-related genes in colorectal carcinogenesis.Scientific reports · 2024Article
- Tumor-Intrinsic Perinuclear LOXL2: Prognostic Relevance and Relationship with YAP1 Activation Status in Oral Squamous Cell Carcinoma.Pathobiology : journal of immunopathology, molecular and cellular biology · 2024Article
- Identification of inflammatory factor-related genes associated with the prognosis and immune cell infiltration in colorectal cancer patients.Genes & diseases · 2023Article
- Histaminergic System and Inflammation-Related Genes in Normal Large Intestine andInternational journal of molecular sciences · 2023Article
- Article
- High throughput, label-free isolation of circulating tumor cell clusters in meshed microwells.Nature communications · 2022Article
- Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells.International journal of molecular sciences · 2022Article
- TSG-6 promotes Cancer Cell aggressiveness in a CD44-Dependent Manner and Reprograms Normal Fibroblasts to create a Pro-metastatic Microenvironment in Colorectal Cancer.International journal of biological sciences · 2022Article
- Review
- TIMP1 intron 3 retention is a marker of colon cancer progression controlled by hnRNPA1.Molecular biology reports · 2020Article
- Dietary Crocin Reverses Melanoma Metastasis.Journal of biomedical research · 2017Article
- Proteins are potent biomarkers to detect colon cancer progression.Saudi journal of biological sciences · 2017Article
- Matrix metalloproteinases in Vietnamese patients with colorectal cancer.Oncology letters · 2017Article
- The 2016 John J. Abel Award Lecture: Targeting the Mechanical Microenvironment in Cancer.Molecular pharmacology · 2016Review
- The effect of LOXL2 in hepatocellular carcinoma.Molecular medicine reports · 2016Article
- Early detection of colorectal cancer: from conventional methods to novel biomarkers.Journal of cancer research and clinical oncology · 2016Review
- Response to Infliximab in Crohn's Disease: Genetic Analysis Supporting Expression Profile.Mediators of inflammation · 2015Article
- Exploration of potential roles of a new LOXL2 splicing variant using network knowledge in esophageal squamous cell carcinoma.TheScientificWorldJournal · 2014Article
- LOXL2 expression is associated with invasiveness and negatively influences survival in breast cancer patients.Breast cancer research and treatment · 2013Article
- MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach.Molecular nutrition & food research · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The balance of activity between the endogenous enzyme inhibitors known as tissue inhibitors of metalloproteinases and their targets, the matrix metalloproteinases, in the extracellular matrix is thought to play an important role in tumour cell invasion. Supporting this notion, we have shown that colorectal cancer patients have increased plasma levels of the tissue inhibitor of metalloproteinases-1 (TIMP-1), and that high plasma TIMP-1 levels are associated with short colorectal cancer patient survival. However, although TIMP-1 has been extensively studied in cancer, very little is known about how it is regulated. To further elucidate potential mechanisms of regulation of this protein, we did a number of experiments to look at associations between the transcript profile of TIMP-1 with known matrix metalloproteinases (MMPs) as well as with expression profiles of other genes differentially regulated in human colorectal cancer (CRC) and the other TIMPs 2-4, which have also been associated with the progression of colorectal cancer. Genome-wide expression profiling of 172 CRC and normal mucosa samples was used to identify transcript changes for the genes under investigation. We found that TIMP-1 was up-regulated in CRC samples compared with normal tissue, while TIMP-2 was down-regulated. Eight MMPs were up-regulated in CRC compared with normal tissue. Correlating up-regulated genes with the TIMP-1 transcript, we identified 13 that were also up-regulated in cancerous tissue. Among these were genes associated with the synthesis of extracellullar matrix, genes involved in the TGF-beta signalling pathway, and genes that are likely transcribed by the tumour cells. These insights add to the complex picture emerging about the regulation of TIMPs in colorectal cancer.
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