ArticleMolecular oncology2008
E2-mediated cathepsin D (CTSD) activation involves looping of distal enhancer elements.
Article in Molecular oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
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- Cathepsins and Their Endogenous Inhibitors in Host Defense DuringFrontiers in immunology · 2021Review
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- Signaling by Steroid Hormones in the 3D Nuclear Space.International journal of molecular sciences · 2018Review
- 3,3'-Diindolylmethane Suppressed Cyprodinil-Induced Epithelial-Mesenchymal Transition and Metastatic-Related Behaviors of Human Endometrial Ishikawa Cells via an Estrogen Receptor-Dependent Pathway.International journal of molecular sciences · 2018Article
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- Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells.Genome biology · 2015Article
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- Nucleosome eviction and multiple co-factor binding predict estrogen-receptor-alpha-associated long-range interactions.Nucleic acids research · 2014Article
- Proteomic signatures of acquired letrozole resistance in breast cancer: suppressed estrogen signaling and increased cell motility and invasiveness.Molecular & cellular proteomics : MCP · 2013Article
- Chromatin immunoprecipitation: advancing analysis of nuclear hormone signaling.Journal of molecular endocrinology · 2012Review
- PES1 promotes breast cancer by differentially regulating ERα and ERβ.The Journal of clinical investigation · 2012Article
- Masculine epigenetic sex marks of the CYP19A1/aromatase promoter in genetically male chicken embryonic gonads are resistant to estrogen-induced phenotypic sex conversion.Biology of reproduction · 2012Article
- Recognition of enhancer element-specific histone methylation by TIP60 in transcriptional activation.Nature structural & molecular biology · 2011Article
- Article
- DamIP: a novel method to identify DNA binding sites in vivo.Nuclear receptor signaling · 2010Article
- E2-mediated cathepsin D (CTSD) activation involves looping of distal enhancer elements.Molecular oncology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Estrogen receptor alpha (ERalpha) is a ligand dependent transcription factor that regulates the expression of target genes through interacting with cis-acting estrogen response elements (EREs). However, only a minority of ERalpha binding sites are located within the proximal promoter regions of responsive genes. Here we report the characterization of an ERE located 9kbp upstream of the TSS of the cathepsin D gene (CTSD) that up-regulates CTSD expression upon estrogen stimulation in MCF-7 cells. Using ChIP, we show recruitment of ERalpha and phosphorylated PolII at the CTSD distal enhancer region. Moreover, we determine the kinetics of transient CpG methylation on the promoter region of CTSD and for the first time, at a distal enhancer element. We show that ERalpha is crucial for long-distance regulation of CTSD expression involving a looping mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.