ArticleMolecular oncology2007
Functional role of Meox2 during the epithelial cytostatic response to TGF-beta.
Article in Molecular oncology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- MEOX2: a homeobox transcription factor with multifaceted biological functions and broad disease associations.Frontiers in cell and developmental biology · 2026Review
- Cabbage Exosome-Like Nanoparticles Encapsulating Small Noncoding tsRNA Prevent Postinjury Arterial Restenosis.Research (Washington, D.C.) · 2025Article
- Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity.Nature communications · 2024Article
- Article
- Characterization and Validation of ceRNA-Mediated Pathway-Pathway Crosstalk Networks Across Eight Major Cardiovascular Diseases.Frontiers in cell and developmental biology · 2022Article
- e-MutPath: computational modeling reveals the functional landscape of genetic mutations rewiring interactome networks.Nucleic acids research · 2021Article
- Facilitation of Bone Healing Processes Based on the Developmental Function ofInternational journal of molecular sciences · 2020Article
- A Novel Prognostic Signature of Transcription Factors for the Prediction in Patients With GBM.Frontiers in genetics · 2019Article
- Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis.Scientific reports · 2016Article
- JNK-dependent gene regulatory circuitry governs mesenchymal fate.The EMBO journal · 2015Article
- MicroRNAs and Cardiac Regeneration.Circulation research · 2015Review
- Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-β.The Journal of cell biology · 2014Article
- Systematic analysis of palatal transcriptome to identify cleft palate genes within TGFβ3-knockout mice alleles: RNA-Seq analysis of TGFβ3 Mice.BMC genomics · 2013Article
- Growth arrest-specific homeobox is associated with poor survival in patients with hepatocellular carcinoma.Medical oncology (Northwood, London, England) · 2012Article
- Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Molecular signaling along the anterior-posterior axis of early palate development.Frontiers in physiology · 2012Article
- miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2.EMBO reports · 2011Article
- Characteristics of highly polymorphic segmental copy-number variations observed in Japanese by BAC-array-CGH.Journal of biomedicine & biotechnology · 2011Article
- Functional role of Meox2 during the epithelial cytostatic response to TGF-beta.Molecular oncology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transforming growth factor beta (TGF-beta) suppresses epithelial cell growth. We have identified a new target gene of the TGF-beta/Smad pathway, Meox2, encoding the homeodomain transcription factor that is known to regulate endothelial cell proliferation and muscle development. Knockdown of endogenous Meox2 by RNA interference prevented the TGF-beta1-induced cytostatic response. Moreover, ectopic Meox2 suppressed epithelial cell proliferation in cooperation with TGF-beta1, and mediated induction of the cell cycle inhibitor gene p21. Transcriptional induction of p21 by Meox2 required a distal region of the p21 promoter that spans the p53-binding site. We show that Meox2 can form protein complexes with Smads leading to cooperative regulation of p21 gene expression. Finally, we found that in cell models that undergo both cell cycle arrest and epithelial-mesenchymal transition (EMT), ectopic Meox2 failed to induce EMT and inhibited the proper EMT response to TGF-beta. Thus, Meox2 is primarily involved in the TGF-beta tumor suppressor pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.