ArticleBMC infectious diseases2009
Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study.
Article in BMC infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Recent advances in pulmonary fibrosis: from lung surfactant to the immune connection.Respiratory research · 2026Review
- Characteristics and prognostic analysis of Pneumocystis jirovecii pneumonia in connective tissue diseases patients with interstitial lung disease: a retrospective study.Clinical rheumatology · 2025Article
- Establishment of an RPA-CRISPR/Cas12a combined diagnostic system for Pneumocystis jirovecii pneumonia.PLoS neglected tropical diseases · 2025Article
- Prognostic Factors for Mortality in Patients With Autoimmune Diseases Complicated by Pneumocystis Pneumonia.Cureus · 2024Article
- High prevalence of pneumocystis pneumonia in interstitial lung disease: a retrospective study.Infection · 2024Article
- Pneumocystis pneumonia in French intensive care units in 2013-2019: mortality and immunocompromised conditions.Annals of intensive care · 2024Article
- Prognostic impact of pre-existing interstitial lung disease in non-HIV patients withERJ open research · 2020Article
- Severe pneumocystis jiroveci pneumonia in a patient on temozolomide therapy: A case report and review of literature.Respiratory medicine case reports · 2017Article
- Efficacy of concurrent treatments in idiopathic pulmonary fibrosis patients with a rapid progression of respiratory failure: an analysis of a national administrative database in Japan.BMC pulmonary medicine · 2016Article
- Survival in Idiopathic pulmonary fibrosis acute exacerbations: the non-steroid approach.BMC pulmonary medicine · 2015Article
- Diagnosis of pneumocystis pneumonia using serum (1-3)-β-D-Glucan: a bivariate meta-analysis and systematic review.Journal of thoracic disease · 2015Article
- (1-3)-beta-D-glucan in association with lactate dehydrogenase as biomarkers of Pneumocystis pneumonia (PcP) in HIV-infected patients.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
- Combined quantification of pulmonary Pneumocystis jirovecii DNA and serum (1->3)-β-D-glucan for differential diagnosis of pneumocystis pneumonia and Pneumocystis colonization.Journal of clinical microbiology · 2013Article
- In-air microparticle induced X-ray emission analysis of particles in interstitial pneumonia lung tissue obtained by transbronchial biopsy.Journal of clinical biochemistry and nutrition · 2011Article
- Pneumocystis jirovecii colonization in chronic pulmonary disease.Parasite (Paris, France) · 2011Review
- Serum (1->3)-beta-D-glucan levels in primary infection and pulmonary colonization with Pneumocystis jirovecii.Journal of clinical microbiology · 2011Article
- Clinical characteristics of Pneumocystis pneumonia in non-HIV patients and prognostic factors including microbiological genotypes.BMC infectious diseases · 2011Article
- Clinical and translational research in pneumocystis and pneumocystis pneumonia.Parasite (Paris, France) · 2011Review
- Management of Pneumocystis Jirovecii pneumonia in HIV infected patients: current options, challenges and future directions.HIV/AIDS (Auckland, N.Z.) · 2010Article
- Clinical evaluation of a (1,3)-beta-D-glucan assay for presumptive diagnosis of Pneumocystis jiroveci pneumonia in immunocompromised patients.Clinical and vaccine immunology : CVI · 2009Article
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7 authors at 2 institutions in 1 country.
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Abstract
backgroundIn patients with chronic respiratory disease, Pneumocystis jirovecii (P. jirovecii) colonization is observed, and may influence disease progression and systemic inflammation. Pneumocystis pneumonia causes interstitial changes, so making a diagnosis of PCP in patients who have interstitial pneumonia (IP) with P. jirovecii colonization is sometimes difficult based on radiography.
methodsThis study investigated the prevalence of P. jirovecii colonization in IP patients and assessed pulmonary injury due to P. jirovecii colonization by measurement of serum markers (KL-6, SP-A, SP-D, and (1-->3) beta-D-glucan (beta-D-glucan)) and the peripheral lymphocyte counts, prospectively. A total of 75 patients with idiopathic pulmonary fibrosis (n = 29), collagen vascular-related interstitial pneumonia (n = 19), chronic bronchitis or pneumonia (n = 20), and Pneumocystis pneumonia (n = 7) were enrolled in this prospective study. P. jirovecii DNA was detected in sputum samples, while serum markers and the lymphocyte count were measured in the peripheral blood.
resultsIP patients (idiopathic pulmonary fibrosis and collagen vascular-related IP) who received oral corticosteroids had a high prevalence of P. jirovecii colonization (23.3%). In IP patients, oral corticosteroid therapy was a significant risk factor for P. jirovecii colonization (P < 0.05). Serum markers did not show differences between IP patients with and without P. jirovecii colonization. The beta-D-glucan level and lymphocyte count differed between patients with Pneumocystis pneumonia or P. jirovecii colonization.
conclusionSerum levels of KL-6, SP-A, SP-D, and beta-D-glucan were not useful for detecting P. jirovecii colonization in IP patients. However, the serum beta-D-glucan level and lymphocyte count were useful for distinguishing P. jirovecii colonization from pneumocystis pneumonia in IP patients.
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