ArticleJournal of cellular and molecular medicine2009
Epicardium: interstitial Cajal-like cells (ICLC) highlighted by immunofluorescence.
Article in Journal of cellular and molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Review
- Telocytes express ANO-1-encoded chloride channels in canine ventricular myocardium.Journal of arrhythmia · 2019Article
- Article
- iPSC-derived human cardiac progenitor cells improve ventricular remodelling via angiogenesis and interstitial networking of infarcted myocardium.Journal of cellular and molecular medicine · 2016Article
- Telocytes in trachea and lungs.Journal of cellular and molecular medicine · 2011Article
- Telocytes and putative stem cells in the lungs: electron microscopy, electron tomography and laser scanning microscopy.Cell and tissue research · 2011Article
- miR-193 expression differentiates telocytes from other stromal cells.Journal of cellular and molecular medicine · 2011Article
- Heterocellular communication in the heart: electron tomography of telocyte-myocyte junctions.Journal of cellular and molecular medicine · 2011Article
- Telocytes in pleura: two- and three-dimensional imaging by transmission electron microscopy.Cell and tissue research · 2011Article
- A dynamic notch injury response activates epicardium and contributes to fibrosis repair.Circulation research · 2011Article
- Cardiac telocytes: serial dynamic images in cell culture.Journal of cellular and molecular medicine · 2010Article
- Telocytes in endocardium: electron microscope evidence.Journal of cellular and molecular medicine · 2010Article
- Telocytes in human epicardium.Journal of cellular and molecular medicine · 2010Article
- Myocardial telocytes: a specific new cellular entity.Journal of cellular and molecular medicine · 2010Review
- TELOCYTES - a case of serendipity: the winding way from Interstitial Cells of Cajal (ICC), via Interstitial Cajal-Like Cells (ICLC) to TELOCYTES.Journal of cellular and molecular medicine · 2010Article
- Cardiomyocyte precursors and telocytes in epicardial stem cell niche: electron microscope images.Journal of cellular and molecular medicine · 2010Article
- Myometrial interstitial cells and the coordination of myometrial contractility.Journal of cellular and molecular medicine · 2009Review
- Human epicardium: ultrastructural ancestry of mesothelium and mesenchymal cells.Journal of cellular and molecular medicine · 2009Article
- Cardiac renewing: interstitial Cajal-like cells nurse cardiomyocyte progenitors in epicardial stem cell niches.Journal of cellular and molecular medicine · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the last few years, there is an increasing interest in the role of the epicardium in cardiac development, myocardial remodelling or repair and regeneration. Several types of cells were described in the subepicardial loose connective tissue, beneath the epicardial mesothe-lium. We showed previously (repeatedly) the existence of interstitial Cajal-like cells (ICLCs) in human and mammalian myocardium, either in atria or in ventricles. Here, we describe ICLCs in adult mice epicardium and primary culture as well as in situ using frozen sections. The identification of ICLCs was based on phase contrast microscopy and immunophenotyping. We found cells with characteristic morphologic aspects: spindle-shaped, triangular or polygonal cell body and typical very long (tens to hundreds micrometres) and very thin cyto-plasmic processes, with a distinctive 'beads-on-a-string' appearance. The dilations contain mitochondria, as demonstrated by MitoTracker Green FM labelling of living cells. Epicardial ICLCs were found positive for c-kit/CD117 and/or CD34. However, we also observed ICLCs positive for c-kit and vimentin. In conclusion, ICLCs represent a distinct cell type in the subendocardium, presumably comprising at least two subpopulations: (i) c-kit/CD34-positive and (ii) only c-kit-positive. ICLCs might be essential as progenitor (or promoter) cells for developing cardiomyocyte lineages in normal and/or injured heart.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.