ArticleDevelopmental biology2009
Diverging functions of Scr between embryonic and post-embryonic development in a hemimetabolous insect, Oncopeltus fasciatus.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Review
- A model system test of trophic transmission of RNA interference effects using the milkweed bug Oncopeltus fasciatus (Hemiptera).Scientific reports · 2026Article
- Dynamic morphological staging of Drosophila pupal development.Scientific reports · 2026Article
- Intraspecific microbiome dynamics across the life cycle of the milkweed bugMicrobial genomics · 2026Article
- Article
- The role of Dmnt1 during spermatogenesis of the insect Oncopeltus fasciatus.Epigenetics & chromatin · 2023Article
- Out from under the wing: reconceptualizing the insect wing gene regulatory network as a versatile, general module for body-wall lobes in arthropods.Proceedings. Biological sciences · 2021Article
- The essential role of Dnmt1 ineLife · 2021Article
- RNAi-Based Functional Genomics in Hemiptera.Insects · 2020Review
- A hemipteran insect reveals new genetic mechanisms and evolutionary insights into tracheal system development.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Three Melanin Pathway Genes,International journal of molecular sciences · 2019Article
- Hox genes mediate the escalation of sexually antagonistic traits in water striders.Biology letters · 2019Article
- Rhinoceros beetle horn development reveals deep parallels with dung beetles.PLoS genetics · 2018Article
- Establishment of molecular genetic approaches to study gene expression and function in an invasive hemipteran,EvoDevo · 2017Article
- Tergal and pleural structures contribute to the formation of ectopic prothoracic wings in cockroaches.Royal Society open science · 2016Article
- Article
- Origin and diversification of wings: Insights from a neopteran insect.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Transcriptome analysis of sexually dimorphic Chinese white wax scale insects reveals key differences in developmental programs and transcription factor expression.Scientific reports · 2015Article
- Insights into the molecular mechanisms underlying diversified wing venation among insects.Proceedings. Biological sciences · 2014Article
- On dorsal prothoracic appendages in treehoppers (Hemiptera: Membracidae) and the nature of morphological evidence.PloS one · 2012Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
Hemimetabolous insects undergo an ancestral mode of development in which embryos hatch into first nymphs that resemble miniature adults. While recent studies have shown that homeotic (hox) genes establish segmental identity of first nymphs during embryogenesis, no information exists on the function of these genes during post-embryogenesis. To determine whether and to what degree hox genes influence the formation of adult morphologies, we performed a functional analysis of Sex combs reduced (Scr) during post-embryonic development in Oncopeltus fasciatus. The main effect was observed in prothorax of Scr-RNAi adults, and ranged from significant alterations in its size and shape to a near complete transformation of its posterior half toward a T2-like identity. Furthermore, while the consecutive application of Scr-RNAi at both of the final two post-embryonic stages (fourth and fifth) did result in formation of ectopic wings on T1, the individual applications at each of these stages did not. These experiments provide two new insights into evolution of wings. First, the role of Scr in wing repression appears to be conserved in both holo- and hemimetabolous insects. Second, the prolonged Scr-depletion (spanning at least two nymphal stages) is both necessary and sufficient to restart wing program. At the same time, other structures that were previously established during embryogenesis are either unaffected (T1 legs) or display only minor changes (labium) in adults. These observations reveal a temporal and spatial divergence of Scr roles during embryonic (main effect in labium) and post-embryonic (main effect in prothorax) development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.