ArticleEndocrine2009
Direct effects of eicosapentaenoic and docosahexaenoic acids on phospholipid and triglyceride fatty acid pattern, glucose metabolism, 86rubidium net uptake and insulin release in BRIN-BD11 cells.
Article in Endocrine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Omega-3 fatty acids control productions of superoxide and nitrogen oxide and insulin content in INS-1E cells.Journal of physiology and biochemistry · 2016Article
- Effect of cytochalasin B on 3-O-[Biomedical reports · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The long-term metabolic and functional effects of a dietary deprivation of long-chain polyunsaturated omega3 fatty acids were recently investigated in second-generation omega3-depleted rats. This study represents the first attempt to explore the direct, but not immediate, effects of omega3 fatty acids on insulin-producing cells. For this purpose, BRIN-BD11 cells were cultured for 24 h in the absence or presence of both C20:5omega3 and C22:6omega3 (50 microM each) and, thereafter, examined for their phospholipid and triglyceride fatty acid pattern, and their metabolic, ionic, and secretory responses to D: -glucose and/or non-nutrient insulinotropic agents. The prior culture in the presence of the two omega3 fatty acids provoked an enrichment of cell lipids in such omega3 fatty acids, changes in the phospholipid fatty acid pattern of long-chain polyunsaturated omega6 fatty acids as well as saturated and monodesaturated fatty acids, and cell steatosis. It minimized the relative increase in D: -[5-(3)H]glucose utilization and D: -[U-(14)C]glucose oxidation otherwise resulting from an increase in the concentration of the hexose from 1.1 to 11.1 mM. It also minimized the changes in (86)Rb(+) net uptake otherwise provoked by rises in D: -glucose concentration and decreased the absolute values for insulin output. It is concluded that the major changes in metabolic, cationic, and secretory behavior of the omega3-enriched BRIN-BD11 cells are paradoxically similar to those encountered in pancreatic islets from omega3-depleted rats and, in both cases, possibly attributable to a phenomenon of lipotoxicity.
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Registered trials
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