ReviewNeurochemical research2009
Pore structure of the Cys-loop ligand-gated ion channels.
Review in Neurochemical research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- 3D-aligned tetrameric ion channels with universal residue labels for comparative structural analysis.Biophysical journal · 2025Article
- Carlos Gutiérrez-Merino: Synergy of Theory and Experimentation in Biological Membrane Research.Molecules (Basel, Switzerland) · 2024Review
- Evolution, Expression, and Function of Nonneuronal Ligand-Gated Chloride Channels in Drosophila melanogaster.G3 (Bethesda, Md.) · 2016Article
- A mutation in the extracellular domain of the α7 nAChR reduces calcium permeability.Pflugers Archiv : European journal of physiology · 2014Article
- Some insights into the binding mechanism of the GABAA receptor: a combined docking and MM-GBSA study.Journal of molecular modeling · 2013Article
- Transmembrane domain V plays a stabilizing role in the function of human bile acid transporter SLC10A2.Biochemistry · 2013Article
- Insights into the neurobiology of the nicotinic cholinergic system and nicotine addiction from mice expressing nicotinic receptors harboring gain-of-function mutations.Pharmacological reviews · 2012Review
- 4-Chloropropofol enhances chloride currents in human hyperekplexic and artificial mutated glycine receptors.BMC neurology · 2012Article
- Transmembrane helix 1 contributes to substrate translocation and protein stability of bile acid transporter SLC10A2.The Journal of biological chemistry · 2011Article
- Rings of charge within the extracellular vestibule influence ion permeation of the 5-HT3A receptor.The Journal of biological chemistry · 2011Article
- NMR structure of the transmembrane domain of the n-acetylcholine receptor beta2 subunit.Biochimica et biophysica acta · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Cys-loop receptor family of ligand-gated ion channels (LGICs) play a key role in synaptic transmission in the central nervous system of animals. Recent advances have led to the elucidation of two crystal structures of related prokaryotic LGICs and the electron micrograph derived structure of the acetylcholine receptor from Torpedo marmorata. Here, we review the structural and biochemical data that form our understanding of the structure of the channel pore. We introduce original data from the glycine receptor using the substituted-cysteine accessibility technique and show that while the helical structure of the segment that surrounds the channel pore is generally agreed, the location of the channel gate, the pore diameter and the structure that forms the entry to the channel pore are likely to differ between receptors. The fundamental structural differences between anion and cation selective receptors and how these differences are related to the pore structure are also considered.
Indexed as
Identifiers
19381804What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.