ArticleEuropean archives of psychiatry and clinical neuroscience2009
The effect of the COMT val(158)met polymorphism on neural correlates of semantic verbal fluency.
Article in European archives of psychiatry and clinical neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- COMT, neuropsychological function and brain structure in schizophrenia: a systematic review and neurobiological interpretation.Journal of psychiatry & neuroscience : JPN · 2013Pooled it
- The role of genetic polymorphisms in executive functioning performance in temporal lobe epilepsy.Epilepsy & behavior : E&B · 2021Article
- Toward the Language Oscillogenome.Frontiers in psychology · 2018Article
- Gene-environment interaction on neural mechanisms of orthographic processing in Chinese children.Journal of neurolinguistics · 2015Article
- A genome-wide supported psychiatric risk variant in NCAN influences brain function and cognitive performance in healthy subjects.Human brain mapping · 2015Article
- Increased neural activity during overt and continuous semantic verbal fluency in major depression: mainly a failure to deactivate.European archives of psychiatry and clinical neuroscience · 2014Article
- A genome-wide supported variant in CACNA1C influences hippocampal activation during episodic memory encoding and retrieval.European archives of psychiatry and clinical neuroscience · 2014Article
- Neuropsychologic assessment in collaborative Parkinson's disease research: a proposal from the National Institute of Neurological Disorders and Stroke Morris K. Udall Centers of Excellence for Parkinson's Disease Research at the University of Pennsylvania and the University of Washington.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2013Article
- Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest.NeuroImage · 2013Article
- Partial support for ZNF804A genotype-dependent alterations in prefrontal connectivity.Human brain mapping · 2013Article
- A Novel Stratification Method in Linkage Studies to Address Inter- and Intra-Family Heterogeneity in Autism.PloS one · 2013Article
- Catechol-O-methyltransferase (COMT) Val158Met polymorphism and risk of osteoporotic fracture.Molecular biology reports · 2012Article
- The effects of a DTNBP1 gene variant on attention networks: an fMRI study.Behavioral and brain functions : BBF · 2010Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Variation in the val(158)met polymorphism of the COMT gene has been found to be associated with cognitive performance. In functional neuroimaging studies, this dysfunction has been linked to signal changes in prefrontal areas. Given the complex modulation and functional heterogeneity of frontal lobe systems, further specification of COMT gene-related phenotypes differing in prefrontally mediated cognitive performance are of major interest. Eighty healthy individuals (54 men, 26 women; mean age 23.3 years) performed an overt semantic verbal fluency task while brain activation was measured with functional magnetic resonance imaging (fMRI). COMT val(158)met genotype was determined and correlated with brain activation measured with fMRI during the task. Although there were no differences in performance, brain activation in the left inferior frontal gyrus [Brodmann area 10] was positively correlated with the number of val alleles in the COMT gene. COMT val(158)met status modulates brain activation during the language production on a semantic level in an area related to executive functions.
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