ArticlePloS one2009
The yeast PNC1 longevity gene is up-regulated by mRNA mistranslation.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- Mistranslation protects against lifespan reduction due to mating in Drosophila melanogaster females.G3 (Bethesda, Md.) · 2026Article
- Codon misreading tRNAs promote tumor growth in mice.RNA biology · 2018Article
- Determinants of the rate of protein sequence evolution.Nature reviews. Genetics · 2015Review
- Regulation of NAD+ metabolism, signaling and compartmentalization in the yeast Saccharomyces cerevisiae.DNA repair · 2014Review
- The evolutionary portrait of metazoan NAD salvage.PloS one · 2013Article
- Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications.RNA biology · 2012Article
- Sirtuins as regulators of the yeast metabolic network.Frontiers in pharmacology · 2012Article
- Molecular characterization of the Borrelia burgdorferi in vivo-essential protein PncA.Microbiology (Reading, England) · 2011Article
- Erratum to: resveratrol and red wine, healthy heart and longevity.Heart failure reviews · 2011Review
- Resveratrol and red wine, healthy heart and longevity.Heart failure reviews · 2010Review
- Regulation of yeast sirtuins by NAD(+) metabolism and calorie restriction.Biochimica et biophysica acta · 2010Review
- Hot topics in aging research: protein translation, 2009.Aging cell · 2009Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Translation fidelity is critical for protein synthesis and to ensure correct cell functioning. Mutations in the protein synthesis machinery or environmental factors that increase synthesis of mistranslated proteins result in cell death and degeneration and are associated with neurodegenerative diseases, cancer and with an increasing number of mitochondrial disorders. Remarkably, mRNA mistranslation plays critical roles in the evolution of the genetic code, can be beneficial under stress conditions in yeast and in Escherichia coli and is an important source of peptides for MHC class I complex in dendritic cells. Despite this, its biology has been overlooked over the years due to technical difficulties in its detection and quantification. In order to shed new light on the biological relevance of mistranslation we have generated codon misreading in Saccharomyces cerevisiae using drugs and tRNA engineering methodologies. Surprisingly, such mistranslation up-regulated the longevity gene PNC1. Similar results were also obtained in cells grown in the presence of amino acid analogues that promote protein misfolding. The overall data showed that PNC1 is a biomarker of mRNA mistranslation and protein misfolding and that PNC1-GFP fusions can be used to monitor these two important biological phenomena in vivo in an easy manner, thus opening new avenues to understand their biological relevance.
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Registered trials
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