ArticlePloS one2009
Identification of novel genes and pathways regulating SREBP transcriptional activity.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
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- Genome-wide identification and annotation of SNPs and their mapping in candidate genes related to milk production and fertility traits in Badri cattle.Tropical animal health and production · 2023Article
- Unveiling the Function of the Mitochondrial Filament-Forming Protein LACTB in Lipid Metabolism and Cancer.Cells · 2022Review
- Reprogramming cholesterol metabolism in macrophages and its role in host defense against cholesterol-dependent cytolysins.Cellular & molecular immunology · 2022Review
- The relationship between nutrition and the immune system.Frontiers in nutrition · 2022Review
- Genome-wide discovery of SNPs in candidate genes related to production and fertility traits in Sahiwal cattle.Tropical animal health and production · 2020Article
- Drug Repurposing Approaches for the Treatment of Influenza Viral Infection: Reviving Old Drugs to Fight Against a Long-Lived Enemy.Frontiers in immunology · 2019Review
- Inhibition of the Interaction Between Group I Metabotropic Glutamate Receptors and PDZ-Domain Proteins Prevents Hippocampal Long-Term Depression, but Not Long-Term Potentiation.Frontiers in synaptic neuroscience · 2019Article
- Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans.American journal of respiratory and critical care medicine · 2016Article
- The expression of neuronal sorting nexin 8 (SNX8) exacerbates abnormal cholesterol levels.Journal of molecular neuroscience : MN · 2014Article
- The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis.The Journal of biological chemistry · 2014Article
- Casein kinase 1 regulates sterol regulatory element-binding protein (SREBP) to control sterol homeostasis.The Journal of biological chemistry · 2014Article
- Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells.The Journal of biological chemistry · 2012Article
- Identification and dissection of four major QTL affecting milk fat content in the German Holstein-Friesian population.PloS one · 2012Article
- Peroxisome-proliferator-activated receptor gamma coactivator 1 α contributes to dysmyelination in experimental models of Huntington's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Dietary unsaturated fatty acids affect the mammary gland integrity and health in lactating dairy cows.BMC proceedings · 2011Article
- Moonlighting function of glycerol kinase causes systems-level changes in rat hepatoma cells.Metabolic engineering · 2010Article
- Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been.Genes & development · 2009Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLipid metabolism in mammals is orchestrated by a family of transcription factors called sterol regulatory element-binding proteins (SREBPs) that control the expression of genes required for the uptake and synthesis of cholesterol, fatty acids, and triglycerides. SREBPs are thus essential for insulin-induced lipogenesis and for cellular membrane homeostasis and biogenesis. Although multiple players have been identified that control the expression and activation of SREBPs, gaps remain in our understanding of how SREBPs are coordinated with other physiological pathways. METHODOLOGY: To identify novel regulators of SREBPs, we performed a genome-wide cDNA over-expression screen to identify proteins that might modulate the transcription of a luciferase gene driven from an SREBP-specific promoter. The results were verified through secondary biological assays and expression data were analyzed by a novel application of the Gene Set Enrichment Analysis (GSEA) method. CONCLUSIONS/SIGNIFICANCE: We screened 10,000 different cDNAs and identified a number of genes and pathways that have previously not been implicated in SREBP control and cellular cholesterol homeostasis. These findings further our understanding of lipid biology and should lead to new insights into lipid associated disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.