ArticlePLoS pathogens2009
A novel role for Stat1 in phagosome acidification and natural host resistance to intracellular infection by Leishmania major.
Article in PLoS pathogens, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- The dsRNA-dependent kinase (PKR) inhibits the growth ofParasitology · 2025Article
- Potential biomarkers of immune protection in human leishmaniasis.Medical microbiology and immunology · 2021Review
- The macrophage microtubule network acts as a key cellular controller of the intracellular fate of Leishmania infantum.PLoS neglected tropical diseases · 2020Article
- Review
- Characterization of Sv129 Mice as a Susceptible Model toFrontiers in medicine · 2019Article
- Toll-interacting protein differentially modulates HIF1α and STAT5-mediated genes in fibroblasts.The Journal of biological chemistry · 2018Article
- Immunology and Genetic ofJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2018Review
- Pathobiology of the 129:Stat1Breast cancer research : BCR · 2017Article
- Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions.PLoS neglected tropical diseases · 2016Article
- Attenuated Leishmania induce pro-inflammatory mediators and influence leishmanicidal activity by p38 MAPK dependent phagosome maturation in Leishmania donovani co-infected macrophages.Scientific reports · 2016Article
- Article
- STAT4 is critical for immunity but not for antileishmanial activity of antimonials in experimental visceral leishmaniasis.European journal of immunology · 2014Article
- Trypanosoma cruzi parasites fight for control of the JAK-STAT pathway by disarming their host.JAK-STAT · 2014Review
- The roles of complement receptor 3 and Fcγ receptors during Leishmania phagosome maturation.Journal of leukocyte biology · 2013Article
- Expression of interferon-induced antiviral genes is delayed in a STAT1 knockout mouse model of Crimean-Congo hemorrhagic fever.Virology journal · 2012Article
- Adjuvant-like effect of vaccinia virus 14K protein: a case study with malaria vaccine based on the circumsporozoite protein.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The diverse and dynamic nature of Leishmania parasitophorous vacuoles studied by multidimensional imaging.PLoS neglected tropical diseases · 2012Article
- The early interaction of Leishmania with macrophages and dendritic cells and its influence on the host immune response.Frontiers in cellular and infection microbiology · 2012Review
- Leishmaniasis: complexity at the host-pathogen interface.Nature reviews. Microbiology · 2011Review
- Abrogating TNF-α expression prevents bystander destruction of normal tissues during iNOS-mediated elimination of intraocular tumors.Cancer research · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Intracellular parasites of the genus Leishmania generate severe diseases in humans, which are associated with a failure of the infected host to induce a protective interferon gamma (IFNgamma)-mediated immune response. We tested the role of the JAK/STAT1 signaling pathway in Leishmania pathogenesis by utilizing knockout mice lacking the signal transducer and activator of transcription 1 (Stat1) and derived macrophages. Unexpectedly, infection of Stat1-deficient macrophages in vitro with promastigotes from Leishmania major and attenuated LPG1 knockout mutants (lpg(-)) specifically lacking lipophosphoglycan (LPG) resulted in a twofold increased intracellular growth, which was independent of IFNgamma and associated with a substantial increase in phagosomal pH. Phagosomes in Stat1-/- macrophages showed normal maturation as judged by the accumulation of the lysosomal marker protein rab7, and provided normal vATPase activity, but were defective in the anion conductive pathway required for full vesicular acidification. Our results suggest a role of acidic pH in the control of intracellular Leishmania growth early during infection and identify for the first time an unexpected role of Stat1 in natural anti-microbial resistance independent from its function as IFNgamma-induced signal transducer. This novel Stat1 function may have important implications to studies of other pathogens, as the acidic phagolysosomal pH plays an important role in antigen processing and the uncoating process of many viruses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.