ArticleGenetics2009
Telomere maintenance and survival in saccharomyces cerevisiae in the absence of telomerase and RAD52.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- To Fix or Not to Fix: Maintenance of Chromosome Ends Versus Repair of DNA Double-Strand Breaks.Cells · 2022Review
- Chromosome-specific telomere lengths and the minimal functional telomere revealed by nanopore sequencing.Genome research · 2022Article
- The many types of heterogeneity in replicative senescence.Yeast (Chichester, England) · 2019Review
- Alternative Lengthening of Telomeres in the Budding YeastG3 (Bethesda, Md.) · 2019Article
- Cis and trans interactions between genes encoding PAF1 complex and ESCRT machinery components in yeast.Current genetics · 2018Article
- Mgm101: A double-duty Rad52-like protein.Cell cycle (Georgetown, Tex.) · 2016Article
- The many facets of homologous recombination at telomeres.Microbial cell (Graz, Austria) · 2015Review
- Interplay between Ku and Replication Protein A in the Restriction of Exo1-mediated DNA Break End Resection.The Journal of biological chemistry · 2015Article
- Two routes to senescence revealed by real-time analysis of telomerase-negative single lineages.Nature communications · 2015Article
- Length-dependent processing of telomeres in the absence of telomerase.Nucleic acids research · 2014Article
- Suppression of chromosome healing and anticheckpoint pathways in yeast postsenescence survivors.Genetics · 2013Article
- Saccharomyces cerevisiae as a Model to Study Replicative Senescence Triggered by Telomere Shortening.Frontiers in oncology · 2013Article
- Long telomeres bypass the requirement for telomere maintenance in human tumorigenesis.Cell reports · 2012Article
- The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis.BMC molecular biology · 2011Article
- From sequence to function: Insights from natural variation in budding yeasts.Biochimica et biophysica acta · 2011Review
- Genome-wide analysis to identify pathways affecting telomere-initiated senescence in budding yeast.G3 (Bethesda, Md.) · 2011Article
- Long telomeres are preferentially extended during recombination-mediated telomere maintenance.Nature structural & molecular biology · 2011Article
- Polymerase epsilon is required to maintain replicative senescence.Molecular and cellular biology · 2011Article
- Taming the tiger by the tail: modulation of DNA damage responses by telomeres.The EMBO journal · 2009Review
- Telomerase reverse transcriptase-dependent telomere equilibration mitigates tissue dysfunction in mTert heterozygotes.Disease models & mechanismsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
Abstract
Telomeres are essential features of linear genomes that are crucial for chromosome stability. Telomeric DNA is usually replenished by telomerase. Deletion of genes encoding telomerase components leads to telomere attrition with each cycle of DNA replication, eventually causing cell senescence or death. In the Saccharomyces cerevisiae strain W303, telomerase-null populations bypass senescence and, unless EXO1 is also deleted, this survival is RAD52 dependent. Unexpectedly, we found that the S. cerevisiae strain S288C could survive the removal of RAD52 and telomerase at a low frequency without additional gene deletions. These RAD52-independent survivors were propagated stably and exhibited a telomere organization typical of recombination between telomeric DNA tracts, and in diploids behaved as a multigenic trait. The polymerase-delta subunit Pol32 was dispensable for the maintenance of RAD52-independent survivors. The incidence of this rare escape was not affected by deletion of other genes necessary for RAD52-dependent survival, but correlated with initial telomere length. If W303 strains lacking telomerase and RAD52 first underwent telomere elongation, rare colonies could then bypass senescence. We suggest that longer telomeres provide a more proficient substrate for a novel telomere maintenance mechanism that does not rely on telomerase, RAD52, or POL32.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.