ArticleJournal of immunology (Baltimore, Md. : 1950)2009
The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 40 citations in OpenAlex.
- Compositional maturation of the microbiome and adaptive immunity in the postnatal period.Frontiers in immunology · 2026Article
- Redox Regulation of LAT Enhances T Cell-Mediated Inflammation.Antioxidants (Basel, Switzerland) · 2024Article
- NSrp70 is a lymphocyte-essential splicing factor that controls thymocyte development.Nucleic acids research · 2021Article
- Naturally Occurring Genetic Alterations in Proximal TCR Signaling and Implications for Cancer Immunotherapy.Frontiers in immunology · 2021Review
- Spontaneous Differentiation of T Follicular Helper Cells in LATY136F Mutant Mice.Frontiers in immunology · 2021Article
- Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination.Nature immunology · 2019Article
- mTOR and other effector kinase signals that impact T cell function and activity.Immunological reviews · 2019Review
- Bridging the Gap: Modulatory Roles of the Grb2-Family Adaptor, Gads, in Cellular and Allergic Immune Responses.Frontiers in immunology · 2019Review
- Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT.Nature immunology · 2018Article
- Tonic Signals: Why Do Lymphocytes Bother?Trends in immunology · 2017Review
- Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.Cell reports · 2017Article
- Phospholipase Cγ1 is required for pre-TCR signal transduction and pre-T cell development.European journal of immunology · 2017Article
- Phorbol ester-mediated re-expression of endogenous LAT adapter in J.CaM2 cells: a model for dissecting drivers and blockers of LAT transcription.Genes and immunity · 2016Article
- Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- The linker for activation of T cells (LAT) signaling hub: from signaling complexes to microclusters.The Journal of biological chemistry · 2015Review
- Diacylglycerol metabolism attenuates T-cell receptor signaling and alters thymocyte differentiation.Cell death & disease · 2013Article
- The requirement of linker for activation of T cells in the primary and memory responses of CD8 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Role of LAT in the granule-mediated cytotoxicity of CD8 T cells.Molecular and cellular biology · 2012Article
- Deconstructing Ras signaling in the thymus.Molecular and cellular biology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The linker for activation of T cells (LAT) is an adaptor protein that couples TCR engagement to downstream signaling cascades. LAT is important in early thymocyte development as LAT-deficient mice have a complete block at the double-negative (DN) 3 stage. To study the role of LAT beyond the DN3 stage, we generated mice in which the lat gene could be deleted by the Cre recombinase. Analysis of these mice showed that deletion of LAT after the DN3 stage allowed thymocytes to develop past the DN3 to DN4 checkpoint and to generate double-positive thymocytes. However, LAT-deficient DP thymocytes were severely defective in responding to stimulation via the TCR and failed to differentiate into single-positive thymocytes efficiently. Consequently, few LAT-deficient mature T cells could be found in the periphery. These T cells had undergone extensive homeostatic proliferation and expressed low levels of the TCR on their surface. Collectively, our data indicate that in addition to its role in pre-TCR signaling, LAT also plays an essential role in thymocyte development during transition from the double-positive to single-positive stage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.