ArticleJPEN. Journal of parenteral and enteral nutrition
Nutrition intervention: a strategy against systemic inflammatory syndrome.
Article in JPEN. Journal of parenteral and enteral nutrition. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- A prospective, randomized, controlled study of ω-3 fish oil fat emulsion-based parenteral nutrition for patients following surgical resection of gastric tumors.Nutrition journal · 2014Trial
- Review
- Bone Marrow Mesenchymal Stem Cells Combat Lipopolysaccharide-Induced Sepsis in Rats via Amendment of P38-MAPK Signaling Cascade.Inflammation · 2018Article
- An immune-modulating formula comprising whey peptides and fermented milk improves inflammation-related remote organ injuries in diet-induced acute pancreatitis in mice.Bioscience of microbiota, food and health · 2018Article
- Nutrients, Infectious and Inflammatory Diseases.Nutrients · 2017Article
- Nutritional and health benefits of semi-elemental diets: A comprehensive summary of the literature.World journal of gastrointestinal pharmacology and therapeutics · 2016Article
- Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2.Critical care medicine · 2016Article
- Protective effect of the ω-3 polyunsaturated fatty acids on the schistosomiasis liver fibrosis in mice.International journal of clinical and experimental medicine · 2015Article
- Diet macronutrients composition in nonalcoholic Fatty liver disease: a review on the related documents.Hepatitis monthly · 2014Review
- Investigation of effect of nutritional drink on chemotherapy-induced mucosal injury and tumor growth in an established animal model.Nutrients · 2013Article
- Review
- Green Tea Polyphenols and Sulfasalazine have Parallel Anti-Inflammatory Properties in Colitis Models.Frontiers in immunology · 2013Article
- Nutrition of the critically ill - emphasis on liver and pancreas.Hepatobiliary surgery and nutrition · 2012Review
- Omega-3 fatty acid improves the clinical outcome of hepatectomized patients with hepatitis B virus (HBV)-associated hepatocellular carcinoma.Journal of biomedical research · 2012Article
- Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents.Nutrition journal · 2012Article
- Chronic inflammation and pain in a tumor necrosis factor receptor (TNFR) (p55/p75-/-) dual deficient murine model.Translational research : the journal of laboratory and clinical medicine · 2012Article
- Fish oil improves hemodynamic stabilization and inflammation after resuscitation in a rat model of hemorrhagic shock.Lipids in health and disease · 2012Article
- Dietary whey protein lowers the risk for metabolic disease in mice fed a high-fat diet.The Journal of nutrition · 2011Article
- The macrophage pattern recognition scavenger receptors SR-A and CD36 protect against microbial induced pregnancy loss.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2011Article
- Effects of L-canavanine and ozone on vascular reactivity in septicemic rats.Journal of physiology and biochemistry · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundSepsis and septic shock syndrome are the leading causes of death in critically ill patients. Lipopolysaccharide (LPS) released by the colonic microorganisms may translocate across a compromised lumen, leading to upregulated reactive oxidative stress, inflammation, and sepsis. The authors examined an enteral formula high in cysteine (antioxidant precursor), omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and prebiotic fructooligosaccharides (FOS) against systemic inflammatory syndrome.
methodsRats were allocated to (1) standard soy-based diet high in cysteine and crude fiber and devoid of EPA-DHA (CHOW); (2) whey-peptide-based liquid diet high in cysteine, EPA-DHA, and FOS (CYSPUFA); or (3) casein-based liquid isonitrogenous diet, low in cysteine and devoid of EPA-DHA-FOS (CASN). Liquid diets provided 25% and CHOW, 23% of calories as protein. After 6 days on diets, rats received an intraperitoneal injection of LPS or saline. Animals gained weight on their respective diets and lost weight after LPS administration. The CYSPUFA group lost considerably less weight (vs CASN or CHOW, P < .05). Inflammatory cytokines significantly increased by 4 hours and subsided 18 hours after assault. The CASN group showed elevated liver enzyme alanine aminotransferase release from damaged hepatocytes and developed severe hepatic pathology with low hematocrit. The CHOW group developed more severe hepatic lesions compared with those on liquid diets. Concentration of liver enzyme and pathology were improved in rats receiving CYSPUFA.
conclusionsData indicate that CYSPUFA, a diet rich in EPA-DHA-FOS, protects against LPS-induced systemic inflammatory responses and warrants clinical studies in critically ill patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.