ArticleProceedings of the National Academy of Sciences of the United States of America2009
Phycomyces MADB interacts with MADA to form the primary photoreceptor complex for fungal phototropism.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 75 citations in OpenAlex.
- Mining Genetically Encoded Biosensors from Filamentous Fungi.Journal of fungi (Basel, Switzerland) · 2026Review
- How fungi see the world: fungal photoreceptors and their role in the regulation of fungal biology.Microbiology and molecular biology reviews : MMBR · 2025Review
- Sequencing the Genomes of the First Terrestrial Fungal Lineages: What Have We Learned?Microorganisms · 2023Review
- Review
- Use of red, far-red, and near-infrared light in imaging of yeasts and filamentous fungi.Applied microbiology and biotechnology · 2022Review
- Transcriptome sequencing and global analysis of blue light-responsive genes provide clues for high carotenoid yields in Blakeslea trispora.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- Identification of the ergC gene involved in polyene drug sensitivity in the Mucorales species Phycomyces blakesleeanus.Molecular biology reports · 2022Article
- A Simple and Low-Cost Strategy to Improve Conidial Yield and Stress Resistance ofJournal of fungi (Basel, Switzerland) · 2022Article
- Structure prediction and function characterization of WC-2 proteins in Blakeslea trispora.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Article
- Ultraviolet Radiation From a Plant Perspective: The Plant-Microorganism Context.Frontiers in plant science · 2020Review
- Distribution, evolution and expression ofPeerJ · 2020Article
- Light sensing and responses in fungi.Nature reviews. Microbiology · 2019Review
- Mystique ofJournal of genetics · 2018Article
- Light-regulated promoters for tunable, temporal, and affordable control of fungal gene expression.Applied microbiology and biotechnology · 2018Review
- A Ras GTPase associated protein is involved in the phototropic and circadian photobiology responses in fungi.Scientific reports · 2017Article
- Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication.Current biology : CB · 2016Article
- A new regulatory mechanism controlling carotenogenesis in the fungus Mucor circinelloides as a target to generate β-carotene over-producing strains by genetic engineering.Microbial cell factories · 2016Article
- Fungal cryptochrome with DNA repair activity reveals an early stage in cryptochrome evolution.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Biological roles of fungal carotenoids.Current genetics · 2015Review
- Article
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
The fungus Phycomyces blakesleeanus reacts to environmental signals, including light, gravity, touch, and the presence of nearby objects, by changing the speed and direction of growth of its fruiting body (sporangiophore). Phototropism, growth toward light, shares many features in fungi and plants but the molecular mechanisms remain to be fully elucidated. Phycomyces mutants with altered phototropism were isolated approximately 40 years ago and found to have mutations in the mad genes. All of the responses to light in Phycomyces require the products of the madA and madB genes. We showed that madA encodes a protein similar to the Neurospora blue-light photoreceptor, zinc-finger protein WC-1. We show here that madB encodes a protein similar to the Neurospora zinc-finger protein WC-2. MADA and MADB interact to form a complex in yeast 2-hybrid assays and when coexpressed in E. coli, providing evidence that phototropism and other responses to light are mediated by a photoresponsive transcription factor complex. The Phycomyces genome contains 3 genes similar to wc-1, and 4 genes similar to wc-2, many of which are regulated by light in a madA or madB dependent manner. We did not detect any interactions between additional WC proteins in yeast 2-hybrid assays, which suggest that MADA and MADB form the major photoreceptor complex in Phycomyces. However, the presence of multiple wc genes in Phycomyces may enable perception across a broad range of light intensities, and may provide specialized photoreceptors for distinct photoresponses.
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