ArticleThe Journal of pharmacology and experimental therapeutics2009
Single-channel analysis of ethanol enhancement of glycine receptor function.
Article in The Journal of pharmacology and experimental therapeutics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Synaptic Effects Induced by Alcohol.Current topics in behavioral neurosciences · 2025Review
- Modulatory Actions of the Glycine Receptor β Subunit on the Positive Allosteric Modulation of Ethanol in α2 Containing Receptors.Frontiers in molecular neuroscience · 2021Article
- Taurine Suppression of Central Amygdala GABAergic Inhibitory Signaling via Glycine Receptors Is Disrupted in Alcohol Dependence.Alcoholism, clinical and experimental research · 2020Article
- High ethanol sensitive glycine receptors regulate firing in D1 medium spiny neurons in the nucleus accumbens.Neuropharmacology · 2019Article
- Activation of glycine receptors in the lateral habenula rescues anxiety- and depression-like behaviors associated with alcohol withdrawal and reduces alcohol intake in rats.Neuropharmacology · 2019Article
- Synaptic targets: Chronic alcohol actions.Neuropharmacology · 2017Review
- Interactions between Zinc and Allosteric Modulators of the Glycine Receptor.The Journal of pharmacology and experimental therapeutics · 2017Article
- Disruption of a putative intersubunit electrostatic bond enhances agonist efficacy at the human α1 glycine receptor.Brain research · 2017Article
- Reversal of Ethanol-induced Intoxication by a Novel Modulator of Gβγ Protein Potentiation of the Glycine Receptor.The Journal of biological chemistry · 2016Article
- Brucine suppresses ethanol intake and preference in alcohol-preferring Fawn-Hooded rats.Acta pharmacologica Sinica · 2014Article
- Synaptic effects induced by alcohol.Current topics in behavioral neurosciences · 2013Review
- Trifluoroacetate is an allosteric modulator with selective actions at the glycine receptor.Neuropharmacology · 2012Article
- Positive allosteric modulators differentially affect full versus partial agonist activation of the glycine receptor.The Journal of pharmacology and experimental therapeutics · 2012Article
- Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.The Journal of pharmacology and experimental therapeutics · 2012Article
- Ethanol enhances taurine-activated glycine receptor function.Alcoholism, clinical and experimental research · 2010Article
- Molecular targets and mechanisms for ethanol action in glycine receptors.Pharmacology & therapeutics · 2010Review
- Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Zinc enhances ethanol modulation of the alpha1 glycine receptor.Neuropharmacology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The glycine receptor (GlyR) is a ligand-gated ion channel and member of the nicotinic acetylcholine receptor superfamily. Acting as allosteric modulators of receptor function, drugs such as alcohol and volatile anesthetics enhance the function of GlyRs. The actions of these drugs at inhibitory receptors in the brain and spinal cord are thought to produce many of the physiological effects associated with their use. The actions of ethanol on the GlyR have been well studied on the macroscopic, whole cell level. We examined the effects of 3 microM glycine +/- 50 or 200 mM ethanol on outside-out patches pulled from Xenopus laevis oocytes expressing wild-type alpha1 GlyR, to determine the effects of alcohol at the single-channel level. Alcohol enhanced GlyR function in a very specific manner. It had minimal effects on open and closed dwell times and likelihood. Instead, ethanol potentiated GlyR function almost exclusively by increasing burst durations and increasing the number of channel openings per burst, without affecting the percentage of open time within bursts. Kinetic modeling suggests that ethanol increases burst durations by decreasing the rate of glycine unbinding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.