ArticleMolecular and cellular biology2009
HIS-24 linker histone and SIR-2.1 deacetylase induce H3K27me3 in the Caenorhabditis elegans germ line.
Article in Molecular and cellular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
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- High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects.Journal of neurochemistry · 2016Article
- Germline-specific H1 variants: the "sexy" linker histones.Chromosoma · 2016Review
- Linker histone H1.2 establishes chromatin compaction and gene silencing through recognition of H3K27me3.Scientific reports · 2015Article
- Defining heterochromatin in C. elegans through genome-wide analysis of the heterochromatin protein 1 homolog HPL-2.Genome research · 2015Article
- Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The controversial world of sirtuins.Drug discovery today. Technologies · 2014Review
- Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.Mitochondrion · 2013Article
- The diversity of histone versus nonhistone sirtuin substrates.Genes & cancer · 2013Article
- Transcriptional repression of Hox genes by C. elegans HP1/HPL and H1/HIS-24.PLoS genetics · 2012Article
- Transgene-mediated cosuppression and RNA interference enhance germ-line apoptosis in Caenorhabditis elegans.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Novel roles of Caenorhabditis elegans heterochromatin protein HP1 and linker histone in the regulation of innate immune gene expression.Molecular and cellular biology · 2012Article
- The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner.Aging cell · 2011Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HIS-24 linker histone and SIR-2.1 deacetylase are involved in chromatin silencing in Caenorhabditis elegans. Depletion of SIR-2.1 results in cytoplasmic retention of HIS-24 in oocytes. However, the molecular working mechanisms of HIS-24 and SIR-2.1 are unclear. We show here a synergistic function of SIR-2.1 and HIS-24 that are together essential for maintenance of the H3K27me3 mark in the germ line of C. elegans. We demonstrate the synthetic effects of the two factors on brood size, embryogenesis, and fertility. SIR-2.1 and HIS-24 associate with the subtelomeric regions but apparently do not interact directly. We report that SIR-2.1 deacetylates H3K9 at subtelomeric regions and suggest that deacetylation of H3K9 is a prerequisite for H3K27 methylation. In turn, we found that HIS-24 specifically interacts with the histone H3 K27 region, when unmodified or in the trimethylated state. Overall, our data indicate that SIR-2.1 and HIS-24 contribute to the propagation of a specialized chromatin state at the subtelomeric regions and elsewhere in the genome.
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