Evidence map›Paper›PMID 19380219›Full record

ArticleProstaglandins, leukotrienes, and essential fatty acids

Associations of maternal prenatal dietary intake of n-3 and n-6 fatty acids with maternal and umbilical cord blood levels.

S M A Donahue, S L Rifas-Shiman, S F Olsen, D R Gold, M W Gillman, E Oken

Abstract read
In one paragraph

Article in Prostaglandins, leukotrienes, and essential fatty acids. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

S M A DonahueObesity Prevention Program, Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Avenue, 3rd Floor, Boston, MA 02215, USA.
S L Rifas-Shiman
S F Olsen
D R Gold
M W Gillman
E Oken
Harvard University · USHarvard Pilgrim Health Care · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Alessio Fasano · 1994 to 2026
$31.6M
Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Pre- and Peri-natal Predictors of Childhood ObesityR37HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2012 to 2015
$4.5M
Patient-oriented research in early life origins of CVDK24HL068041 · NHLBI · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2001 to 2010
$1.4M
Maternal fatty acids, birth weight and child developmentK23HD044807 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2003 to 2007
$662k
NHLBI NIH HHS K24 HL068041NICHD NIH HHS HD34568NICHD NIH HHS HD44807NICHD NIH HHS HD68041NICHD NIH HHS K23 HD044807NICHD NIH HHS R01 HD034568NICHD NIH HHS R37 HD034568NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

Maternal n-3 and n-6 polyunsaturated fatty acid (PUFA) status may influence birth outcomes and child health. We assessed second trimester maternal diet with food frequency questionnaires (FFQs) (n=1666), mid-pregnancy maternal erythrocyte PUFA concentrations (n=1550), and umbilical cord plasma PUFA concentrations (n=449). Mean (SD) maternal intake of total n-3 PUFA was 1.17 g/d (0.43), docosahexaenoic and eicosapentaenoic acids (DHA+EPA) 0.16 g/d (0.17), and total n-6 PUFA 12.25 g/d (3.25). Mean maternal erythrocyte and cord plasma PUFA concentrations were 7.0% and 5.2% (total n-3), 5.0% and 4.6% (DHA+EPA), and 27.9% and 31.4% (total n-6). Mid-pregnancy diet-blood and blood-blood correlations were strongest for DHA+EPA (r=0.38 for diet with maternal blood, r=0.34 for diet with cord blood, r=0.36 for maternal blood with cord blood), and less strong for n-6 PUFA. The FFQ is a reliable measure of elongated PUFA intake, although inter-individual variation is present.

Indexed as

Prenatal Nutritional Physiological PhenomenaErythrocytesFatty Acids, Omega-3Fatty Acids, Omega-6FemaleFetal BloodHumansMaternal-Fetal ExchangePregnancyPregnancy Trimester, SecondPrenatal Exposure Delayed EffectsFatty Acids, Omega-3Fatty Acids, Omega-6

Identifiers

PMID19380219
PMCPMC3939614
OpenAlexW2098413510

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.