ArticleInternational journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience2009
Estradiol promotes proliferation of dopaminergic precursors resulting in a higher proportion of dopamine neurons derived from mouse embryonic stem cells.
Article in International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 24 citations in OpenAlex.
- Markers of Pluripotency in Human Amniotic Epithelial Cells and Their Differentiation to Progenitor of Cortical Neurons.PloS one · 2015Article
- Recovery from experimental parkinsonism by semaphorin-guided axonal growth of grafted dopamine neurons.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- Systemic administration of valproic acid and zonisamide promotes differentiation of induced pluripotent stem cell-derived dopaminergic neurons.Frontiers in cellular neuroscience · 2013Article
- Small molecules greatly improve conversion of human-induced pluripotent stem cells to the neuronal lineage.Stem cells international · 2012Article
- Conceptualizing the role of estrogens and serotonin in the development and maintenance of bulimia nervosa.Clinical psychology review · 2010Review
- Axon responses of embryonic stem cell-derived dopaminergic neurons to semaphorins 3A and 3C.Journal of neuroscience research · 2010Article
- Progesterone increases dopamine neurone number in differentiating mouse embryonic stem cells.Journal of neuroendocrinology · 2009Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Estradiol protects dopamine neurons of the substantia nigra from toxic insults. Such neurons succumb in Parkinson's disease; one strategy for restoring dopamine deficiency is cell therapy with neurons differentiated from embryonic stem cells. We investigated the effects of 17beta-estradiol on dopaminergic induction of embryonic stem cells using the 5-stage protocol. Cells were incubated with different steroid concentrations during the proliferation (stage 4) or differentiation (stage 5) phases. Estradiol added at nM concentrations only during stage 4 increases the proliferation of dopaminergic precursors expressing Lmx1a, inducing a higher proportion of dopamine neurons at stage 5. These actions were mediated by activation of estrogen receptors, because co-incubation of cells with estradiol and ICI 182,780 completely abolished the positive effect on both proliferation of committed precursors, and subsequent differentiation to dopaminergic neurons. Our results suggest that estradiol should be useful in producing higher proportions of dopamine neurons from embryonic stem cells aimed for treating Parkinson's disease.
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