ArticleBehavioural brain research2009
Animal models of gene-environment interactions in schizophrenia.
Article in Behavioural brain research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Positive Association of TEAD1 With Schizophrenia in a Northeast Chinese Han Population.Psychiatry investigation · 2023Article
- The Gene Polymorphism of VMAT2 Is Associated with Risk of Schizophrenia in Male Han Chinese.Psychiatry investigation · 2020Article
- Resolving and Rescuing Developmental Miswiring in a Mouse Model of Cognitive Impairment.Neuron · 2020Article
- Molecular substrates of schizophrenia: homeostatic signaling to connectivity.Molecular psychiatry · 2016Review
- Gene × Environment Interactions in Schizophrenia: Evidence from Genetic Mouse Models.Neural plasticity · 2016Review
- Copy Number Variations in DISC1 and DISC1-Interacting Partners in Major Mental Illness.Molecular neuropsychiatry · 2015Article
- Complexin2 modulates working memory-related neural activity in patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2015Article
- Chronic Toxoplasma gondii in Nurr1-null heterozygous mice exacerbates elevated open field activity.PloS one · 2015Article
- Genetics of schizophrenia.Current psychiatry reports · 2014Review
- Chronic exposure of mutant DISC1 mice to lead produces sex-dependent abnormalities consistent with schizophrenia and related mental disorders: a gene-environment interaction study.Schizophrenia bulletin · 2014Article
- Maternal care affects the phenotype of a rat model for schizophrenia.Frontiers in behavioral neuroscience · 2014Article
- Mouse models of gene-environment interactions in schizophrenia.Neurobiology of disease · 2013Review
- Neuregulin 1: a prime candidate for research into gene-environment interactions in schizophrenia? Insights from genetic rodent models.Frontiers in behavioral neuroscience · 2013Article
- New insights into behaviour using mouse ENU mutagenesis.Human molecular genetics · 2012Review
- Advancing schizophrenia drug discovery: optimizing rodent models to bridge the translational gap.Nature reviews. Drug discovery · 2012Review
- Is lead exposure in early life an environmental risk factor for Schizophrenia? Neurobiological connections and testable hypotheses.Neurotoxicology · 2012Review
- Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood.The European journal of neuroscience · 2012Article
- Prenatal immune activation interacts with genetic Nurr1 deficiency in the development of attentional impairments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Better understanding of mechanisms of schizophrenia and bipolar disorder: from human gene expression profiles to mouse models.Neurobiology of disease · 2012Review
- The conundrums of understanding genetic risks for autism spectrum disorders.Nature neuroscience · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The pathogenesis of schizophrenia and related mental illnesses likely involves multiple interactions between susceptibility genes of small effects and environmental factors. Gene-environment interactions occur across different stages of neurodevelopment to produce heterogeneous clinical and pathological manifestations of the disease. The main obstacle for mechanistic studies of gene-environment interplay has been the paucity of appropriate experimental systems for elucidating the molecular pathways that mediate gene-environment interactions relevant to schizophrenia. Recent advances in psychiatric genetics and a plethora of experimental data from animal studies allow us to suggest a new approach to gene-environment interactions in schizophrenia. We propose that animal models based on identified genetic mutations and measurable environment factors will help advance studies of the molecular mechanisms of gene-environment interplay.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.