ArticleBMC infectious diseases2009
Invasive Haemophilus influenzae infections in Germany: impact of non-type b serotypes in the post-vaccine era.
Article in BMC infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Impact of a Single-Tube PCR Assay for the Detection ofMicroorganisms · 2022Article
- Long Term Impact of Conjugate Vaccines onMicroorganisms · 2021Review
- InvasiveOpen forum infectious diseases · 2020Article
- Epidemiology of Invasive Haemophilus influenzae Disease, Europe, 2007-2014.Emerging infectious diseases · 2017Article
- The evidence for non-typeablePneumonia (Nathan Qld.) · 2017Article
- Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016.Annals of hematology · 2016Article
- Public health microbiology in Germany: 20 years of national reference centers and consultant laboratories.International journal of medical microbiology : IJMM · 2015Review
- Identification of Haemophilus influenzae clones associated with invasive disease a decade after introduction of H. influenzae serotype b vaccination in Italy.Clinical and vaccine immunology : CVI · 2013Article
- Invasive Haemophilus influenzae in the United States, 1999-2008: epidemiology and outcomes.The Journal of infection · 2012Article
- Invasive Haemophilus influenzae serotype e and f disease, England and Wales.Emerging infectious diseases · 2012Article
- Phosphorylcholine allows for evasion of bactericidal antibody by Haemophilus influenzae.PLoS pathogens · 2012Article
- Haemophilus influenzae infections in the H. influenzae type b conjugate vaccine era.Journal of clinical microbiology · 2011Review
- The causative organisms of bacterial meningitis in Korean children in 1996-2005.Journal of Korean medical science · 2010Article
- Comparison of PCR-based methods for the simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in clinical samples.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHaemophilus influenzae type b (Hib) vaccination led to a significant decrease in invasive bacterial infections in children. The aim of this study was to assess a potential shift to more non-type b invasive infections in a population with high Hib vaccination coverage and to compare the burden of suffering between children with Hib, capsulated non-b and non-capsulated Hi infections.
methodsCases with confirmed invasive Hi infections were ascertained through two independent nationwide active surveillance systems in 1998-2005. Information on possible predisposing conditions and clinical information was available from 2001 onwards.
resultsThe total number of reported non-type b Hi cases varied between 10 cases in 1998, 27 in 2000 and 14 in 2005. In each year, non-capsulated serotypes outnumbered capsulated non-type b ones. 192 cases were detected in 2001-2005, more than one half was non-type b and 88% of the non-type b cases were non-capsulated. For cases with Hib/capsulated non-type b infections the most common clinical presentation was meningitis (67% each); 89%/78% had no potential predisposing condition, 75%/72% completely recovered from disease and 6% (each) died. In contrast, meningitis was diagnosed in 34% of the non-capsulated Hi infections, septicaemia in 28% and pneumonia 21%; 62% had no potential predisposing condition, 83% completely recovered and 3% died.
conclusionThere was no increase in non-type b Hi invasive infections during 8 years of active surveillance in Germany. Invasive disease due to non-type b Hi is not confined to children with risk factors. In patients with capsulated non-type b Hi infections the proportion of meningitis cases is similar to Hib, but double as high as in non-capsulated Hi.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.