Evidence map›Paper›PMID 19378149›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2009

Promoter analysis: gene regulatory motif identification with A-GLAM.

Leonardo Mariño-Ramírez, Kannan Tharakaraman, John L Spouge, David Landsman

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Characterization of the Metallothionein Gene Family inAntioxidants (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Leonardo Mariño-RamírezComputational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, MD, USA.
Kannan Tharakaraman
John L Spouge
David Landsman

Funding

Gene Regulatory Sequences And Protein Binding in Genome SequencesZIALM000084 · NLM · NATIONAL LIBRARY OF MEDICINE · PI LANDSMAN, DAVID · 2009 to 2025
$7.7M
The Analysis of Signal Elements in Promoter Sequences.ZIALM091704 · NLM · NATIONAL LIBRARY OF MEDICINE · PI SPOUGE, JOHN · 2009 to 2017
$1.4M
Intramural NIH HHS Z99 LM999999
6 · The paper itself

Abstract

Reliable detection of cis-regulatory elements in promoter regions is a difficult and unsolved problem in computational biology. The intricacy of transcriptional regulation in higher eukaryotes, primarily in metazoans, could be a major driving force of organismal complexity. Eukaryotic genome annotations have improved greatly due to large-scale characterization of full-length cDNAs, transcriptional start sites (TSSs), and comparative genomics. Regulatory elements are identified in promoter regions using a variety of enumerative or alignment-based methods. Here we present a survey of recent computational methods for eukaryotic promoter analysis and describe the use of an alignment-based method implemented in the A-GLAM program.

Indexed as

AlgorithmsBase SequenceComputational BiologyGenomicsMolecular Sequence DataPromoter Regions, GeneticSequence Analysis, DNA

Identifiers

PMID19378149
PMCPMC2702474

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.