ArticleNature neuroscience2009
Synaptic mGluR activation drives plasticity of calcium-permeable AMPA receptors.
Article in Nature neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 79 citations in OpenAlex.
- Gating and noelin clustering of native CaNature · 2025Article
- The mGluR5-mediated Arc activation protects against experimental traumatic brain injury in rats.CNS neuroscience & therapeutics · 2024Article
- Distinct GABAergic modulation of timing-dependent LTP in CA1 pyramidal neurons along the longitudinal axis of the mouse hippocampus.iScience · 2024Article
- Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications.Neural regeneration research · 2024Review
- CaThe Journal of physiology · 2021Article
- Drug-Evoked Synaptic Plasticity of Excitatory Transmission in the Ventral Tegmental Area.Cold Spring Harbor perspectives in medicine · 2021Review
- NMDA receptor-dependent long-term depression in the lateral habenula: implications in physiology and depression.Scientific reports · 2020Article
- Article
- mGlu1 tonically regulates levels of calcium-permeable AMPA receptors in cultured nucleus accumbens neurons through retinoic acid signaling and protein translation.The European journal of neuroscience · 2019Article
- Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity.Molecular neuropsychiatry · 2019Review
- Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice.Nature communications · 2019Article
- Emergence of Endocytosis-Dependent mGlu1 LTD at Nucleus Accumbens Synapses After Withdrawal From Cocaine Self-Administration.Frontiers in synaptic neuroscience · 2018Article
- AMPA Receptor Plasticity in Accumbens Core Contributes to Incubation of Methamphetamine Craving.Biological psychiatry · 2016Article
- Topological Regulation of Synaptic AMPA Receptor Expression by the RNA-Binding Protein CPEB3.Cell reports · 2016Article
- mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output.Cell reports · 2016Article
- Synaptic AMPA receptor composition in development, plasticity and disease.Nature reviews. Neuroscience · 2016Review
- Article
- A Model of In vitro Plasticity at the Parallel Fiber-Molecular Layer Interneuron Synapses.Frontiers in computational neuroscience · 2015Article
- Group I mGluR-dependent depotentiation in the lateral amygdala does not require the removal of calcium-permeable AMPA receptors.Frontiers in behavioral neuroscience · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In contrast with conventional NMDA receptor-dependent synaptic plasticity, the synaptic events controlling the plasticity of GluR2-lacking Ca(2+)-permeable AMPA receptors (CP-AMPARs) remain unclear. At parallel fiber synapses onto cerebellar stellate cells, Ca(2+) influx through AMPARs triggers a switch in AMPAR subunit composition, resulting in loss of Ca(2+) permeabilty. Paradoxically, synaptically induced depolarization will suppress this Ca(2+) entry by promoting polyamine block of CP-AMPARs. We therefore examined other mechanisms that may control this receptor regulation under physiological conditions. We found that activation of both mGluRs and CP-AMPARs is necessary and sufficient to drive an AMPAR subunit switch and that by enhancing mGluR activity, GABA(B)R activation promotes this plasticity. Furthermore, we found that mGluRs and GABA(B)Rs are tonically activated, thus setting the basal tone for EPSC amplitude and rectification. Regulation by both excitatory and inhibitory inputs provides an unexpected mechanism that determines the potential of these synapses to show dynamic changes in AMPAR Ca(2+) permeability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.