ArticleNature chemical biology2009
Opportunities in metabolic engineering to facilitate scalable alkaloid production.
Article in Nature chemical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Herbgenomics meets Papaveraceae: a promising -omics perspective on medicinal plant research.Briefings in functional genomics · 2024Review
- Metabolic engineering of Saccharomyces cerevisiae for chelerythrine biosynthesis.Microbial cell factories · 2024Article
- Engineering cascade biocatalysis in whole cells for syringic acid bioproduction.Microbial cell factories · 2024Article
- Engineered biosynthesis of plant heteroyohimbine and corynantheine alkaloids in Saccharomyces cerevisiae.Journal of industrial microbiology & biotechnology · 2024Article
- Mining cancer genomes for change-of-metabolic-function mutations.Communications biology · 2023Article
- Recent trends in biocatalysis.Chemical Society reviews · 2021Review
- Biosynthesis and synthetic biology of psychoactive natural products.Chemical Society reviews · 2021Review
- Native and non-native host assessment towards metabolic pathway reconstructions of plant natural products.Biotechnology reports (Amsterdam, Netherlands) · 2021Review
- Total Synthesis of (-)-Strictosidine and Interception of Aryne Natural Product Derivatives "Strictosidyne" and "Strictosamidyne".Journal of the American Chemical Society · 2021Article
- Recent Advances in Heterologous Synthesis Paving Way for Future Green-Modular Bioindustries: A Review With Special Reference to Isoflavonoids.Frontiers in bioengineering and biotechnology · 2021Review
- Broadening the scope of biocatalytic C-C bond formation.Nature reviews. Chemistry · 2020Article
- Article
- Engineered mitochondrial production of monoterpenes in Saccharomyces cerevisiae.Metabolic engineering · 2019Article
- Metabolic and transcriptional analyses in response to potent inhibitors establish MEP pathway as major route for camptothecin biosynthesis in Nothapodytes nimmoniana (Graham) Mabb.BMC plant biology · 2019Article
- Tempo-Spatial Pattern of Stepharine Accumulation inInternational journal of molecular sciences · 2019Article
- Furan-Site Bromination and Transformations of Fraxinellone as Insecticidal Agents Against Mythimna separata Walker.Scientific reports · 2018Article
- Cyanobacteria: Promising biocatalysts for sustainable chemical production.The Journal of biological chemistry · 2018Review
- Development of a Method to Extract Opium Poppy (Papaver somniferum L.) DNA from Heroin.Scientific reports · 2018Article
- Engineering the biocatalytic selectivity of iridoid production in Saccharomyces cerevisiae.Metabolic engineering · 2017Article
- Accelerating the semisynthesis of alkaloid-based drugs through metabolic engineering.Nature chemical biology · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Numerous drugs and drug precursors in the current pharmacopoeia originate from plant sources. The limited yield of some bioactive compounds in plant tissues, however, presents a significant challenge for large-scale drug development. Metabolic engineering has facilitated the development of plant cell and tissue systems as alternative production platforms that can be scaled up in a controlled environment. Nevertheless, effective metabolic engineering approaches and the predictability of genetic transformations are often obscured due to the myriad cellular complexities. Progress in systems biology has aided the understanding of genome-wide interconnectivities in plant-based systems. In parallel, the bottom-up assembly of plant biosynthetic pathways in microorganisms demonstrated the possibilities of a new means of production. In this Perspective, we discuss the opportunities and challenges of implementing metabolic engineering in various platforms for the synthesis of natural and unnatural plant alkaloids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.