ReviewCell cycle (Georgetown, Tex.)2009
DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation.
Review in Cell cycle (Georgetown, Tex.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 169 citations in OpenAlex.
- AtGADD45A forms a complex with the scaffold protein AtRACK1A in response to DNA damage.Plant cell reports · 2025Article
- Ginger Polyphenols Reverse Molecular Signature of Amygdala Neuroimmune Signaling and Modulate Microbiome in Male Rats with Neuropathic Pain: Evidence for Microbiota-Gut-Brain Axis.Antioxidants (Basel, Switzerland) · 2024Article
- Impact of GADD45A on Radiation Biodosimetry Using Mouse Peripheral Blood.Radiation research · 2023Article
- DNA Damage Response-Associated Cell Cycle Re-Entry and Neuronal Senescence in Brain Aging and Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Review
- The Role of DNA Methylation in Stroke Recovery.International journal of molecular sciences · 2022Review
- GADD45 in Stress Signaling, Cell Cycle Control, and Apoptosis.Advances in experimental medicine and biology · 2022Article
- The role of TET proteins in stress-induced neuroepigenetic and behavioural adaptations.Neurobiology of stress · 2021Review
- Proteins in DNA methylation and their role in neural stem cell proliferation and differentiation.Cell regeneration (London, England) · 2021Review
- Regulation of dopamine-dependent transcription and cocaine action by Gadd45b.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- An Extracellular Perspective on CNS Maturation: Perineuronal Nets and the Control of Plasticity.International journal of molecular sciences · 2021Review
- Article
- The role of MeCP2 in learning and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Epigenetic regulation of histone H3 in the process of hepatocellular tumorigenesis.Bioscience reports · 2019Review
- Hyper-activation of Aurora kinase a-polo-like kinase 1-FOXM1 axis promotes chronic myeloid leukemia resistance to tyrosine kinase inhibitors.Journal of experimental & clinical cancer research : CR · 2019Article
- The DNA Repair-Associated Protein Gadd45γ Regulates the Temporal Coding of Immediate Early Gene Expression within the Prelimbic Prefrontal Cortex and Is Required for the Consolidation of Associative Fear Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Brain Functional Reserve in the Context of Neuroplasticity after Stroke.Neural plasticity · 2019Review
- Molecular Mechanisms Underlying the Link between Diet and DNA Methylation.International journal of molecular sciences · 2018Review
- Epigenetic Changes Associated with Early Life Experiences: Saliva, A Biospecimen for DNA Methylation Signatures.Current genomics · 2018Article
- Telomeric epigenetic response mediated by Gadd45a regulates stem cell aging and lifespan.EMBO reports · 2018Article
- 5-hydroxymethylcytosine in DNA repair: A new player or a red herring?Cell cycle (Georgetown, Tex.) · 2017Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
DNA cytosine methylation represents an intrinsic modification signal of the genome that plays important roles in heritable gene silencing, heterochromatin formation and certain transgenerational epigenetic inheritance. In contrast to the process of DNA methylation that is catalyzed by specific classes of methyltransferases, molecular players underlying active DNA demethylation have long been elusive. Emerging biochemical and functional evidence suggests that active DNA demethylation in vertebrates can be mediated through DNA excision repair enzymes, similar to the well-known repair-based DNA demethylation mechanism in Arabidopsis. As key regulators, non-enzymatic Gadd45 proteins function to recruit enzymatic machineries and promote coupling of deamination, base and nucleotide-excision repair in the process of DNA demethylation. In this article, we review recent findings and discuss functional and evolutionary implications of such mechanisms underlying active DNA demethylation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.