ArticleGenome research2009
High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues.
Article in Genome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 77 citations in OpenAlex.
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- Association mapping across a multitude of traits collected in diverse environments in maize.GigaScience · 2022Article
- Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation.PLoS genetics · 2020Article
- Post-genomic behavioral genetics: From revolution to routine.Genes, brain, and behavior · 2018Review
- Lead ModulatesFrontiers in genetics · 2018Article
- Substantial contribution of genetic variation in the expression of transcription factors to phenotypic variation revealed by eRD-GWAS.Genome biology · 2017Article
- Genome-wide dissection of heterosis for yield traits in two-line hybrid rice populations.Scientific reports · 2017Article
- Heterogeneous Stock Populations for Analysis of Complex Traits.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Genetic Variation in the Social Environment Contributes to Health and Disease.PLoS genetics · 2017Article
- GeneNetwork: A Toolbox for Systems Genetics.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression.G3 (Bethesda, Md.) · 2016Article
- Article
- Genome-wide association study of behavioral, physiological and gene expression traits in outbred CFW mice.Nature genetics · 2016Article
- Modelling local gene networks increases power to detect trans-acting genetic effects on gene expression.Genome biology · 2016Article
- Differences between Mice and Humans in Regulation and the Molecular Network of Collagen, Type III, Alpha-1 at the Gene Expression Level: Obstacles that Translational Research Must Overcome.International journal of molecular sciences · 2015Article
- A random forest approach to capture genetic effects in the presence of population structure.Nature communications · 2015Article
- A genetic interaction network model of a complex neurological disease.Genes, brain, and behavior · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
A proportion of the genetic variants underlying complex phenotypes do so through their effects on gene expression, so an important challenge in complex trait analysis is to discover the genetic basis for the variation in transcript abundance. So far, the potential of mapping both quantitative trait loci (QTLs) and expression quantitative trait loci (eQTLs) in rodents has been limited by the low mapping resolution inherent in crosses between inbred strains. We provide a megabase resolution map of thousands of eQTLs in hippocampus, lung, and liver samples from heterogeneous stock (HS) mice in which 843 QTLs have also been mapped at megabase resolution. We exploit dense mouse SNP data to show that artifacts due to allele-specific hybridization occur in approximately 30% of the cis-acting eQTLs and, by comparison with exon expression data, we show that alternative splicing of the 3' end of the genes accounts for <1% of cis-acting eQTLs. Approximately one third of cis-acting eQTLs and one half of trans-acting eQTLs are tissue specific. We have created an important systems biology resource for the genetic analysis of complex traits in a key model organism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.