ArticleApplied and environmental microbiology2009
Regulation of expression of genes involved in quinate and shikimate utilization in Corynebacterium glutamicum.
Article in Applied and environmental microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
- A Comprehensive Review on the Pharmacological Activities and Biosynthetic Strategies of Protocatechuic Acid.Life (Basel, Switzerland) · 2026Review
- Optimizing a carbon source based on water temperature to reduceFrontiers in systems biology · 2026Article
- Robertkochia aurantiaca sp. nov., and Robertkochia flava sp. nov., two potential quinate- and catechol-degrading bacteria isolated from tidal-flat sediments.Antonie van Leeuwenhoek · 2025Article
- Two routes for tyrosol production by metabolic engineering of Corynebacterium glutamicum.Biotechnology for biofuels and bioproducts · 2025Article
- Production of aromatic amino acids and their derivatives by Escherichia coli and Corynebacterium glutamicum.World journal of microbiology & biotechnology · 2025Review
- The effect on shikimate production by deletingFrontiers in bioengineering and biotechnology · 2025Article
- Biosensors for the detection of chorismate and cis,cis-muconic acid in Corynebacterium glutamicum.Journal of industrial microbiology & biotechnology · 2024Article
- Improving growth properties of Corynebacterium glutamicum by implementing an iron-responsive protocatechuate biosynthesis.Microbial biotechnology · 2023Article
- Improvement in L-ornithine production from mannitol via transcriptome-guided genetic engineering in Corynebacterium glutamicum.Biotechnology for biofuels and bioproducts · 2022Article
- Physiological Response ofMicroorganisms · 2020Article
- COmBio · 2020Article
- Article
- Quantum chemistry reveals thermodynamic principles of redox biochemistry.PLoS computational biology · 2018Article
- Corynebacterium glutamicum as platform for the production of hydroxybenzoic acids.Microbial cell factories · 2018Article
- Production of 4-Hydroxybenzoic Acid by an Aerobic Growth-Arrested Bioprocess Using Metabolically Engineered Corynebacterium glutamicum.Applied and environmental microbiology · 2018Article
- Gene stacking of multiple traits for high yield of fermentable sugars in plant biomass.Biotechnology for biofuels · 2018Article
- Genomic changes associated with the evolutionary transition of an insect gut symbiont into a blood-borne pathogen.The ISME journal · 2017Article
- Expression of a bacterial 3-dehydroshikimate dehydratase reduces lignin content and improves biomass saccharification efficiency.Plant biotechnology journal · 2015Article
- Genome-wide analysis of the role of global transcriptional regulator GntR1 in Corynebacterium glutamicum.Journal of bacteriology · 2014Article
- The LacI-Type transcriptional regulator AraR acts as an L-arabinose-responsive repressor of L-arabinose utilization genes in Corynebacterium glutamicum ATCC 31831.Journal of bacteriology · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The utilization of the hydroaromatic compounds quinate and shikimate by Corynebacterium glutamicum was investigated. C. glutamicum grew well with either quinate or shikimate as the sole carbon source. The disruption of qsuD, encoding quinate/shikimate dehydrogenase, completely suppressed growth with either substrate but did not affect growth with glucose, indicating that the enzyme encoded by qsuD catalyzes the first step of the catabolism of quinate/shikimate but is not involved in the shikimate pathway required for the biosynthesis of various aromatic compounds. On the chromosome of C. glutamicum, the qsuD gene is located in a gene cluster also containing qsuA, qsuB, and qsuC genes, which are probably involved in the quinate/shikimate utilization pathway to form protocatechuate. Reverse transcriptase PCR analyses revealed that the expression of the qsuABCD genes was markedly induced during growth with either quinate or shikimate relative to expression during growth with glucose. The induction level by shikimate was significantly decreased by the disruption of qsuR, which is located immediately upstream of qsuA in the opposite direction and encodes a LysR-type transcriptional regulator, suggesting that QsuR acts as an activator of the qsuABCD genes. The high level of induction of qsuABCD genes by shikimate was still observed in the presence of glucose, and simultaneous consumption of glucose and shikimate during growth was observed.
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