ArticleApplied and environmental microbiology2009
Induction of extracellular hydroxyl radical production by white-rot fungi through quinone redox cycling.
Article in Applied and environmental microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 153 citations in OpenAlex.
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- Substrate specificity mapping of fungal CAZy AA3_2 oxidoreductases.Biotechnology for biofuels and bioproducts · 2024Article
- Induction of Extracellular Hydroxyl Radicals Production in the White-Rot FungusJournal of fungi (Basel, Switzerland) · 2024Article
- Synergistic lignin degradation between Phanerochaete chrysosporium and Fenton chemistry is mediated through iron cycling and ligninolytic enzyme induction.The Science of the total environment · 2023Article
- Construction of white-rot fungal-bacterial consortia with improved ligninolytic properties and stable bacterial community structure.ISME communications · 2023Article
- β-Alanine Metabolism Leads to Increased Extracellular pH during the Heterotrophic Ammonia Oxidation ofMicroorganisms · 2023Article
- Lignin Metabolism by Selected Fungi and Microbial Consortia for Plant Stimulation: Implications for Biologically Active Humus Genesis.Microbiology spectrum · 2022Article
- Natural detoxification of antibiotics in the environment: A one health perspective.Frontiers in microbiology · 2022Review
- A Putative Lignin Copper Oxidase fromJournal of fungi (Basel, Switzerland) · 2021Article
- Oxic and Anoxic Organic Polymer Degradation Potential of Endophytic Fungi From the Marine Macroalga,Frontiers in microbiology · 2021Article
- Review
- Outer membrane vesicles catabolize lignin-derived aromatic compounds inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Infection Strategies Deployed byFrontiers in plant science · 2019Article
- Deciphering lignocellulose deconstruction by the white rot fungusBiotechnology for biofuels · 2018Article
- Enhancement of Environmental Hazard Degradation in the Presence of Lignin: a Proteomics Study.Scientific reports · 2017Article
- Carbon Source-Dependent Inducible Metabolism of Veratryl Alcohol and Ferulic Acid in Pseudomonas putida CSV86.Applied and environmental microbiology · 2017Article
- Effects of Homologous Expression of 1,4-Benzoquinone Reductase and Homogentisate 1,2-Dioxygenase Genes on Wood Decay in Hyper-Lignin-Degrading Fungus Phanerochaete sordida YK-624.Current microbiology · 2016Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A simple strategy for the induction of extracellular hydroxyl radical (OH) production by white-rot fungi is presented. It involves the incubation of mycelium with quinones and Fe(3+)-EDTA. Succinctly, it is based on the establishment of a quinone redox cycle catalyzed by cell-bound dehydrogenase activities and the ligninolytic enzymes (laccase and peroxidases). The semiquinone intermediate produced by the ligninolytic enzymes drives OH production by a Fenton reaction (H(2)O(2) + Fe(2+) --> OH + OH(-) + Fe(3+)). H(2)O(2) production, Fe(3+) reduction, and OH generation were initially demonstrated with two Pleurotus eryngii mycelia (one producing laccase and versatile peroxidase and the other producing just laccase) and four quinones, 1,4-benzoquinone (BQ), 2-methoxy-1,4-benzoquinone (MBQ), 2,6-dimethoxy-1,4-benzoquinone (DBQ), and 2-methyl-1,4-naphthoquinone (menadione [MD]). In all cases, OH radicals were linearly produced, with the highest rate obtained with MD, followed by DBQ, MBQ, and BQ. These rates correlated with both H(2)O(2) levels and Fe(3+) reduction rates observed with the four quinones. Between the two P. eryngii mycelia used, the best results were obtained with the one producing only laccase, showing higher OH production rates with added purified enzyme. The strategy was then validated in Bjerkandera adusta, Phanerochaete chrysosporium, Phlebia radiata, Pycnoporus cinnabarinus, and Trametes versicolor, also showing good correlation between OH production rates and the kinds and levels of the ligninolytic enzymes expressed by these fungi. We propose this strategy as a useful tool to study the effects of OH radicals on lignin and organopollutant degradation, as well as to improve the bioremediation potential of white-rot fungi.
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