ReviewProgress in retinal and eye research2009
Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases.
Review in Progress in retinal and eye research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05803798 (Combined Treatment With Pulsed Light and Photobiomodulation Before Laser Refractive Surgery), which is not on this map. Cited by 243 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Combined Treatment With Pulsed Light and Photobiomodulation Before Laser Refractive Surgery
Who cites it
243 citing papers in PubMed, 3 syntheses or guidelines pooled it, 475 citations in OpenAlex.
- Safety and Efficacy of Diquafosol Compared to Artificial Tears for the Treatment of Dry Eye: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- The efficacy and safety of varenicline nasal spray for the management of dry eye signs: a systematic review and meta-analysis.BMC ophthalmology · 2023Pooled it
- TFOS lifestyle: Impact of societal challenges on the ocular surface.The ocular surface · 2023Pooled it
- Varenicline Solution Nasal Spray for the Treatment of Dry Eye Disease in Sjogren's Disease: A Pilot Study.Clinical ophthalmology (Auckland, N.Z.) · 2025Trial
- Effect of laughter exercise versus 0.1% sodium hyaluronic acid on ocular surface discomfort in dry eye disease: non-inferiority randomised controlled trial.BMJ (Clinical research ed.) · 2024Trial
- Extract fromNutrients · 2024Trial
- The Effects of Chewing Gum in Preventing Eyestrain.BioMed research international · 2020Trial
- Randomized Controlled Crossover Trial Comparing the Impact of Sham or Intranasal Tear Neurostimulation on Conjunctival Goblet Cell Degranulation.American journal of ophthalmology · 2017Trial
- Trial
- Non-invasive estimation of hydration status changes through tear fluid osmolarity during exercise and post-exercise rehydration.European journal of applied physiology · 2015Trial
- Autonomic Nerve Fiber Compositions of Zygomaticotemporal and Lacrimal Nerves: A Cadaveric Immunohistochemical Analysis.International forum of allergy & rhinology · 2026Article
- Detection of α-synuclein seeding activity in tear fluid as a candidate biomarker for Parkinson's disease.Journal of Parkinson's disease · 2026Article
- Partial orbital lobe dacryoadenectomy for refractory epiphora.Indian journal of ophthalmology · 2026Article
- Chitinases in Tear Fluid of Patients With Amyotrophic Lateral Sclerosis.European journal of neurology · 2026Article
- Monitoring and addressing anticholinergic-induced ocular adverse effects associated with psychotropic medication.The mental health clinician · 2026Article
- Inflammasomes in Sjögren's Disease: Exploring the Therapeutic Value.International journal of molecular sciences · 2026Review
- Lute-GenAntioxidants (Basel, Switzerland) · 2026Article
- Ocular IL-1α/IFN-γ Delay the Corneal Wound Healing in Rheumatoid Arthritis Through Mitochondrial Dysfunction and NLRP3 Inflammasome Activation.Investigative ophthalmology & visual science · 2026Article
- Evaluation of corneal morphology, pupillometry, and ocular surface parameters in Fabry disease patients: correlation with plasma Lyso-Gb3 levels.International ophthalmology · 2026Article
- Review
183 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The lacrimal gland is the major contributor to the aqueous layer of the tear film which consists of water, electrolytes and proteins. The amount and composition of this layer is critical for the health, maintenance, and protection of the cells of the cornea and conjunctiva (the ocular surface). Small changes in the concentration of tear electrolytes have been correlated with dry eye syndrome. While the mechanisms of secretion of water, electrolytes and proteins from the lacrimal gland differ, all three are under tight neural control. This allows for a rapid response to meet the needs of the cells of the ocular surface in response to environmental conditions. The neural response consists of the activation of the afferent sensory nerves in the cornea and conjunctiva to stimulate efferent parasympathetic and sympathetic nerves that innervate the lacrimal gland. Neurotransmitters are released from the stimulated parasympathetic and sympathetic nerves that cause secretion of water, electrolytes, and proteins from the lacrimal gland and onto the ocular surface. This review focuses on the neural regulation of lacrimal gland secretion under normal and dry eye conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.