Evidence map›Paper›PMID 19376240›Full record

Trial reportNeuroImage2009

An fMRI study of cytokine-induced depressed mood and social pain: the role of sex differences.

Naomi I Eisenberger, Tristen K Inagaki, Lian T Rameson, Nehjla M Mashal, Michael R Irwin

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in NeuroImage, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00949845 (An fMRI Study of Cytokine-Associated Depression and Social Pain), which is not on this map. Cited by 152 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed, 7 pooled it
4.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00949845 early_phase1completednot on this map

An fMRI Study of Cytokine-Associated Depression and Social Pain

TypeinterventionalSponsorUniversity of California, Los AngelesRan2007ConditionsDepressionArmsEndotoxin
3 · Its place in the literature

Who cites it

152 citing papers in PubMed, 7 syntheses or guidelines pooled it, 307 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. A meta-analysis of the anterior cingulate contribution to social pain.Social cognitive and affective neuroscience · 2015
    Pooled it
  7. The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011
    Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Moderators for depressed mood and systemic and transcriptional inflammatory responses: a randomized controlled trial of endotoxin.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Naomi I EisenbergerDepartment of Psychology, University of California, Los Angeles, CA 90095-1563, USA. neisenbe@ucla.edu
Tristen K Inagaki
Lian T Rameson
Nehjla M Mashal
Michael R Irwin
University of California, Los Angeles · USNorthwestern University · USSalk Institute for Biological Studies · US

Funding

ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOORE, ALISON AHERN · 2006 to 2017
$9.8M
Aging: Sleep and Inflammatory Mechanisms in Depression PreventionR01AG026364 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2005 to 2015
$5.8M
Sleep and Immune Mechanisms in Rheumatoid ArthritisR01HL079955 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 2006 to 2009
$3.0M
Post-Graduate Training Program in Psychoneuroimmunology and Mental HealthT32MH019925 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 1997 to 2012
$1.7M
Combinatorial Genomics in CancerR01CA116778 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COLE, STEVE W · 2006 to 2010
$1.5M
NCI NIH HHS CA-10014152NCI NIH HHS CA-116778NCI NIH HHS R01 CA116778NCRR NIH HHS M01 RR000865NCRR NIH HHS M01-RR00865NHLBI NIH HHS HL-079955NHLBI NIH HHS R01 HL079955NIA NIH HHS AG-026364NIA NIH HHS P30 AG028748NIA NIH HHS P30-AG028748NIA NIH HHS R01 AG026364NIMH NIH HHS T32 MH019925NIMH NIH HHS T32-MH19925
6 · The paper itself

Abstract

Although research has demonstrated a relationship between proinflammatory cytokine activity and depressive symptoms, the neurocognitive processes underlying this relationship have remained largely unexplored. Here, we examined the effect of proinflammatory cytokine activation on the neural correlates of socially painful experience and associated depressed mood. Participants received either low-dose endotoxin or placebo through intravenous injection. Levels of the proinflammatory cytokine, IL-6, were repeatedly assessed through hourly blood draws; self-reported depressed mood was assessed hourly as well. Two hours post-injection, participants completed a neuroimaging session in which they were socially excluded during an online ball-tossing game. Replicating previous research, individuals exposed to endotoxin, compared to placebo, showed increases in IL-6 levels and depressed mood. Although there were no meaningful differences between the endotoxin and control groups in neural responses to social exclusion, there were sex differences in the relationships between IL-6 increases and neural responses to exclusion among subjects exposed to endotoxin. Among females, but not males, exposed to endotoxin, increases in IL-6 were associated with increases in social pain-related neural activity (dorsal anterior cingulate cortex, anterior insula) that mediated the relationship between IL-6 increases and depressed mood increases. Implications of these sex differences in the neural correlates of cytokine-associated depressed mood and social pain are discussed.

Indexed as

Brain MappingSex CharacteristicsSocial IsolationAdolescentAdultCytokinesDepressionEndotoxinsEstradiolFemaleHumansHydrocortisoneImage Processing, Computer-AssistedInterleukin-6Magnetic Resonance ImagingMaleCytokinesEndotoxinsEstradiolHydrocortisoneInterleukin-6Progesterone

Identifiers

PMID19376240
PMCPMC2733873
OpenAlexW2143741117

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.