ReviewNeuroscience2009
Insights into brain development from neurogenetic syndromes: evidence from fragile X syndrome, Williams syndrome, Turner syndrome and velocardiofacial syndrome.
Review in Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Verbal narrative ability and episodic autobiographical memory in adolescents and young adults with 22q11.2 deletion syndrome.Journal of neurodevelopmental disorders · 2025Article
- Organ Abnormalities Caused by Turner Syndrome.Cells · 2023Review
- Article
- Structural and functional brain alterations revealed by neuroimaging in CNV carriers.Current opinion in genetics & development · 2021Review
- Common and specific impairments in attention functioning in girls with chromosome 22q11.2 deletion, fragile X or Turner syndromes.Journal of neurodevelopmental disorders · 2014Article
- Reprint of: Mapping connectivity in the developing brain.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2014Article
- Disrupted working memory circuitry and psychotic symptoms in 22q11.2 deletion syndrome.NeuroImage. Clinical · 2014Article
- Mapping connectivity in the developing brain.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2013Article
- Article
- Typical and atypical brain development: a review of neuroimaging studies.Dialogues in clinical neuroscience · 2013Review
- Genetic contributions to changes of fiber tracts of ventral visual stream in 22q11.2 deletion syndrome.Brain imaging and behavior · 2013Article
- The genomically mosaic brain: aneuploidy and more in neural diversity and disease.Seminars in cell & developmental biology · 2013Review
- Comprehensive neurocognitive endophenotyping strategies for mouse models of genetic disorders.Progress in neurobiology · 2012Review
- Epigenetic transgenerational actions of endocrine disruptors.Reproductive toxicology (Elmsford, N.Y.) · 2011Article
- Clues to the foundations of numerical cognitive impairments: evidence from genetic disorders.Developmental neuropsychology · 2011Review
- Epigenetic transgenerational actions of environmental factors in disease etiology.Trends in endocrinology and metabolism: TEM · 2010Review
- From the genome to the phenome and back: linking genes with human brain function and structure using genetically informed neuroimaging.Neuroscience · 2009Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
Over the past few decades, behavioral, neuroimaging and molecular studies of neurogenetic conditions, such as Williams, fragile X, Turner and velocardiofacial (22q11.2 deletion) syndromes, have led to important insights regarding brain development. These investigations allow researchers to examine "experiments of nature" in which the deletion or alteration of one gene or a contiguous set of genes can be linked to aberrant brain structure or function. Converging evidence across multiple imaging modalities has now begun to highlight the abnormal neural circuitry characterizing many individual neurogenetic syndromes. Furthermore, there has been renewed interest in combining analyses across neurogenetic conditions in order to search for common organizing principles in development. In this review, we highlight converging evidence across syndromes from multiple neuroimaging modalities, with a particular emphasis on functional imaging. In addition, we discuss the commonalities and differences pertaining to selective deficits in visuospatial processing that occur across four neurogenetic syndromes. We suggest avenues for future exploration, with the goal of achieving a deeper understanding of the neural abnormalities in these affected populations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.