ArticlePharmacology, biochemistry, and behavior2009
Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion.
Article in Pharmacology, biochemistry, and behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Endogenous regulator of G protein signaling 14 (RGS14) blunts cocaine-induced emotionally motivated behaviors in female mice.Addiction neuroscience · 2025Article
- The influence of drug class on reward in substance use disorders.Pharmacology, biochemistry, and behavior · 2024Review
- Cholesterol modulation of interactions between psychostimulants and dopamine transporters.Advances in pharmacology (San Diego, Calif.) · 2024Article
- Impact of fluoxetine preexposure on MDMA-induced taste avoidance in male and female rats.Experimental and clinical psychopharmacology · 2023Article
- Reinforcing and Stimulant-Like Effects of Methamphetamine Isomers in Rhesus Macaques.The Journal of pharmacology and experimental therapeutics · 2021Article
- 3,4-Methylenedioxypyrovalerone (MDPV)-induced conditioned taste avoidance in the F344/N and LEW rat strains.Pharmacology, biochemistry, and behavior · 2014Article
- Unique genetic factors influence sensitivity to the rewarding and aversive effects of methamphetamine versus cocaine.Behavioural brain research · 2013Article
- Cocaine produces conditioned place aversion in mice with a cocaine-insensitive dopamine transporter.Genes, brain, and behavior · 2013Article
- Adolescent male rats are less sensitive than adults to the anxiogenic and serotonin-releasing effects of fenfluramine.Neuropharmacology · 2013Article
- Dopamine mediates cocaine-induced conditioned taste aversions as demonstrated with cross-drug preexposure to GBR 12909.Pharmacology, biochemistry, and behavior · 2012Article
- Profound reduction in sensitivity to the aversive effects of methamphetamine in mice bred for high methamphetamine intake.Neuropharmacology · 2012Article
- Translating the smoking cessation properties of the antidepressant nortriptyline using reinforcing, discriminative and aversive stimulus effects of nicotine in rats.Psychopharmacology · 2012Article
- Sensitivity to rewarding or aversive effects of methamphetamine determines methamphetamine intake.Genes, brain, and behavior · 2011Article
- Dopamine, norepinephrine and serotonin transporter gene deletions differentially alter cocaine-induced taste aversion.Pharmacology, biochemistry, and behavior · 2010Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Despite the impact of cocaine's aversive effects on its abuse potential, the neurochemical basis of these aversive effects remains poorly understood. By blocking the reuptake of the monoamine neurotransmitters dopamine (DA), norepinephrine (NE) and serotonin (5-HT) into the presynaptic terminal, cocaine acts as a potent indirect agonist of each of these systems. The following studies attempted to assess the extent of monoaminergic mediation of cocaine's aversive effects using conditioned taste aversion (CTA) learning [Garcia, J., Kimeldorf, D.J., Koelling, R.A., Conditioned aversion to saccharin resulting from exposure to gamma radiation. Science 1955;122:157-158.]. Specifically, Experiment 1 assessed the ability of selective monoamine transporter inhibitors, e.g., DAT (vanoxerine), NET (nisoxetine) and SERT (fluoxetine), to induce taste aversions (relative to cocaine). Only the NET inhibitor approximated the aversive strength of cocaine. Experiment 2 compared the effects of pretreatment of each of these transport inhibitors on the development of a cocaine-induced CTA. Pretreatment with nisoxetine and fluoxetine both attenuated cocaine-induced aversions in a manner comparable to that produced by cocaine itself. The DAT inhibitor was without effect. Combined, the results of these investigations indicate little or no involvement of dopaminergic systems in cocaine's aversive effects while NE appears to contribute most substantially, with a possible modulatory involvement by serotonin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.