ArticleImmunology1991
A role for intestinal T lymphocytes in bronchus mucosal immunity.
Article in Immunology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Oral non-typable Haemophilus influenzae enhances physiological mechanism of airways protection.Clinical and experimental immunology · 2010Trial
- Review
- An Oral Whole-Cell Killed NontypeableInternational journal of chronic obstructive pulmonary disease · 2019Review
- Osteopathic lymphatic pump techniques to enhance immunity and treat pneumonia.International journal of osteopathic medicine : IJOM · 2012Article
- Acute exacerbations in COPD and their control with oral immunization with non-typeable haemophilus influenzae.Frontiers in immunology · 2011Article
- Lymphatic pump treatment augments lymphatic flux of lymphocytes in rats.Lymphatic research and biology · 2010Article
- Lymphatic pump treatment mobilizes leukocytes from the gut associated lymphoid tissue into lymph.Lymphatic research and biology · 2010Article
- Effector mechanisms of protection against Pseudomonas aeruginosa keratitis in immunized rats.Infection and immunity · 2001Article
- CD8+ T cells have an essential role in pulmonary clearance of nontypeable Haemophilus influenzae following mucosal immunization.Infection and immunity · 2001Article
- Bombesin recovers gut-associated lymphoid tissue and preserves immunity to bacterial pneumonia in mice receiving total parenteral nutrition.Annals of surgery · 2000Article
- A P5 peptide that is homologous to peptide 10 of OprF from Pseudomonas aeruginosa enhances clearance of nontypeable Haemophilus influenzae from acutely infected rat lung in the absence of detectable peptide-specific antibody.Infection and immunity · 2000Article
- Respiratory mucosal immunization with reovirus serotype 1/L stimulates virus-specific humoral and cellular immune responses, including double-positive (CD4(+)/CD8(+)) T cells.Journal of virology · 1999Article
- Characterization of the gene encoding a 26-kilodalton protein (OMP26) from nontypeable Haemophilus influenzae and immune responses to the recombinant protein.Infection and immunity · 1999Article
- Early childhood infection and atopic disorder.Thorax · 1998Article
- Nontypeable Haemophilus influenzae: pathogenesis and prevention.Microbiology and molecular biology reviews : MMBR · 1998Article
- Bronchiolitis obliterans in ataxia-telangiectasia.Virchows Archiv : an international journal of pathology · 1997Article
- Isolation and functional characterization of T cells from human sputum.Clinical and experimental immunology · 1995Article
- Changes in cytokine and nitric oxide secretion by rat alveolar macrophages after oral administration of bacterial extracts.Clinical and experimental immunology · 1995Article
- Enhanced respiratory clearance of nontypeable Haemophilus influenzae following mucosal immunization with P6 in a rat model.Infection and immunity · 1995Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rats immunized by intra-Peyer's patch (IPP) injection with non-typable Haemophilus influenzae (NTHI) have been shown to clear this organism from the respiratory tract faster than non-immunized rats. We therefore performed a series of experiments in order to determine the mechanism of action of the enhanced pulmonary clearance. The experiments show that homing of intestinal T cells to the respiratory tract is an important component in the observed immunity, while specific antibody adsorbed to bacteria does not influence pulmonary bacterial clearance rate. Mucosally derived lymphocytes were collected from the thoracic duct of rats primed by IPP inoculation with NTHI, and intravenously transfused to recipient rats. These rats were shown to clear bacteria from bronchial spaces faster than non-transfused rats, or rats transfused with non-immune lymphocytes. Lymphocytes collected from the spleens of immunized rats were also capable of conferring the ability to accelerate pulmonary clearance. When thoracic duct lymphocytes (TDL) purified for T lymphocytes were transferred to recipients, the NTHI clearance rate was accelerated. In experiments to evaluate the activity of specific antibody, it was demonstrated that NTHI opsonized with antibody from bronchial washings of immunized rats was not cleared from the respiratory tract of naive rats faster than non-opsonized controls. These data indicate that immune clearance of NTHI from the respiratory tract following gut immunization is dependent upon antigen-primed lymphocytes, that primed T cells are capable of conferring this protection, and that a primary role for specific antibody in the process cannot be established.
Indexed as
Identifiers
1937575PMC1384673W1942876What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.