ArticleExperimental hematology2009
Extramedullary erythropoiesis in the adult liver requires BMP-4/Smad5-dependent signaling.
Article in Experimental hematology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 55 citations in OpenAlex.
- Lung Epithelium Releases Growth Differentiation Factor 15 in Response to Pathogen-mediated Injury.American journal of respiratory cell and molecular biology · 2024Article
- Role of Macrophages in Sickle Cell Disease Erythrophagocytosis and Erythropoiesis.International journal of molecular sciences · 2023Review
- An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis.Experimental hematology · 2022Article
- Mechanisms of 8-aminoquinoline induced haemolytic toxicity in a G6PDd humanized mouse model.Journal of cellular and molecular medicine · 2022Article
- Article
- Targeting Stress Erythropoiesis Pathways in Cancer.Frontiers in physiology · 2022Review
- Histidine decarboxylase deficiency inhibits NBP-induced extramedullary hematopoiesis by modifying bone marrow and spleen microenvironments.International journal of hematology · 2021Article
- Dynamic changes in murine erythropoiesis from birth to adulthood: implications for the study of murine models of anemia.Blood advances · 2021Article
- Differences in Steady-State Erythropoiesis in Different Mouse Bones and Postnatal Spleen.Frontiers in cell and developmental biology · 2021Article
- Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits.Nature genetics · 2020Article
- Splenectomy Modulates the Erythrocyte Turnover and Basigin (CD147) Expression in Mice.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2020Article
- Stress erythropoiesis: definitions and models for its study.Experimental hematology · 2020Review
- Nitric oxide-dependent expansion of erythroid progenitors in a murine model of chronic psychological stress.Histochemistry and cell biology · 2020Article
- Gdf15 regulates murine stress erythroid progenitor proliferation and the development of the stress erythropoiesis niche.Blood advances · 2019Article
- Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia.Blood · 2018Article
- Stress Erythropoiesis Model Systems.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Spinal cord compression secondary to extramedullary hematopoiesis: A rareness in a young adult with thalassemia major.Acta bio-medica : Atenei Parmensis · 2017Article
- Severe trauma and chronic stress activates extramedullary erythropoiesis.The journal of trauma and acute care surgery · 2017Article
- Nitrogen-containing bisphosphonate induces a newly discovered hematopoietic structure in the omentum of an anemic mouse model by stimulating G-CSF production.Cell and tissue research · 2017Article
- Development and differentiation of the erythroid lineage in mammals.Developmental and comparative immunology · 2016Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveIn mice, homeostatic erythropoiesis occurs primarily in the bone marrow. However, in response to acute anemia, bone morphogenetic proteins 4 (BMP-4)-dependent stress erythropoiesis occurs in the adult spleen. BMP-4 can also regulate stress erythropoiesis in the fetal liver. In humans, erythropoiesis occurs in the bone marrow. However, in certain pathological conditions, extramedullary erythropoiesis is observed, where it can occur in several organs, including the liver. Given these observations, we propose to investigate whether the BMP-4-dependent stress erythropoiesis pathway can regulate extramedullary erythropoiesis in the livers of splenectomized mice. MATERIALS AND
methodsUsing splenectomized wild-type and flexed-tail (f) mice, which have a defect in BMP-4 signaling, we compared their recovery from phenylhydrazine-induced hemolytic anemia and characterized the expansion of stress burst-forming unit-erythroid in the livers of these mice during the recovery period.
resultsOur analysis indicates that in the absence of a spleen, stress erythropoiesis occurs in the murine liver. During the recovery, stress burst-forming unit-erythroid are expanded in the livers of splenectomized mice in response to BMP-4 expressed in the liver. f/f mice, which exhibit a defect in splenic stress erythropoiesis do not compensate for this defect by upregulating liver stress erythropoiesis. Furthermore, splenectomized f/f mice exhibit a defect in liver stress erythropoiesis, which demonstrates a role for the BMP-4-dependent stress erythropoiesis pathway in extramedullary erythropoiesis in the adult liver.
conclusionsOur data indicate that the BMP-4-dependent stress erythropoiesis pathway regulates extramedullary stress erythropoiesis, which occurs primarily in the murine spleen or in the case of splenectomized mice, in the adult liver.
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