ArticleExperimental hematology2009
Activation of the macrophage A2b adenosine receptor regulates tumor necrosis factor-alpha levels following vascular injury.
Article in Experimental hematology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 48 citations in OpenAlex.
- CD73/adenosine dynamics in treatment-induced pneumonitis: balancing efficacy with risks of adverse events in combined radio-immunotherapies.Frontiers in cell and developmental biology · 2024Review
- Hypoxia-adenosine axis as therapeutic targets for acute respiratory distress syndrome.Frontiers in immunology · 2024Review
- A2BAR Antagonism Decreases the Glomerular Expression and Secretion of Chemoattractants for Monocytes and the Pro-Fibrotic M2 Macrophages Polarization during Diabetic Nephropathy.International journal of molecular sciences · 2023Article
- Mesenchymal Stromal Cell Exosomes Mediate M2-like Macrophage Polarization through CD73/Ecto-5'-Nucleotidase Activity.Pharmaceutics · 2023Article
- A2B Adenosine Receptor in Idiopathic Pulmonary Fibrosis: Pursuing Proper Pit Stop to Interfere with Disease Progression.International journal of molecular sciences · 2023Review
- Alternative adenosine Receptor activation: The netrin-Adora2b link.Frontiers in pharmacology · 2022Review
- Targeting purinergic receptors to suppress the cytokine storm induced by SARS-CoV-2 infection in pulmonary tissue.International immunopharmacology · 2021Review
- Can Adenosine Fight COVID-19 Acute Respiratory Distress Syndrome?Journal of clinical medicine · 2020Review
- Purinergic Signaling in Pulmonary Inflammation.Frontiers in immunology · 2019Review
- Infarct-Sparing Effect of Adenosine A2B Receptor Agonist Is Primarily Due to Its Action on Splenic Leukocytes Via a PI3K/Akt/IL-10 Pathway.The Journal of surgical research · 2018Article
- Differential Tissue-Specific Function of Adora2b in Cardioprotection.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Adenosine 2B Receptor Activation Reduces Myocardial Reperfusion Injury by Promoting Anti-Inflammatory Macrophages Differentiation via PI3K/Akt Pathway.Oxidative medicine and cellular longevity · 2015Article
- Purinergic signalling and immune cells.Purinergic signalling · 2014Review
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- Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages.Journal of leukocyte biology · 2013Article
- Regulation of inflammation by adenosine.Frontiers in immunology · 2013Article
- Adora2b adenosine receptor signaling protects during acute kidney injury via inhibition of neutrophil-dependent TNF-α release.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Adora2b signaling on bone marrow derived cells dampens myocardial ischemia-reperfusion injury.Anesthesiology · 2012Article
- Hypoxia signaling during intestinal ischemia and inflammation.Current opinion in critical care · 2012Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe control of expression of tumor necrosis factor-alpha (TNF-alpha) impacts a variety of processes during a stress response. Macrophages are a major source of TNF-alpha, the level of which is known to be regulated by adenosine. Previous studies highlighted the role of the A2a adenosine receptor in this process, while the role of the A2b adenosine receptor (A2bAR) has not been clearly identified. Here, we examined the contribution of the A2bAR to TNF-alpha regulation by macrophages at baseline and under vascular stress. MATERIALS AND
methodsWe employed a newer A2bAR-selective ligand, BAY 60-6583 in vitro and in vivo, and an A2bAR antagonist CVT-6883, as well as examined macrophages derived from control or A2bAR knockout mice.
resultsWe found that the expression of the A2bAR is upregulated in macrophages derived from wild-type mice subjected to arterial injury, and this receptor activity controls the level of TNF-alpha released from macrophages.
conclusionWe identified a significant role for the A2bAR in the regulation of TNF-alpha, which would contribute to the anti-inflammatory actions of adenosine under vascular stress. This conclusion could focus attention on this receptor as a therapeutic target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.